Evidence map›Paper›PMID 38778101›Full record

ArticleNature2024

Selective haematological cancer eradication with preserved haematopoiesis.

Simon Garaudé, Romina Marone, Rosalba Lepore, Anna Devaux, Astrid Beerlage, Denis Seyres, Alessandro Dell' Aglio, Darius Juskevicius, Jessica Zuin, Thomas Burgold and 18 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
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  17. Mobilization meets antibody conditioning: A path toward safer engraftment.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  18. Review
  19. Article
  20. Pioneering biomimetic biomaterial for leukemia therapy enhancement: a review.Frontiers in bioengineering and biotechnology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Simon Garaudé *Department of Biomedicine, Basel University Hospital and University of Basel, Basel, Switzerland.ORCID 0000-0003-3474-4895
Romina Marone *Department of Biomedicine, Basel University Hospital and University of Basel, Basel, Switzerland.ORCID 0000-0003-1474-1689
Rosalba LeporeDepartment of Biomedicine, Basel University Hospital and University of Basel, Basel, Switzerland.ORCID 0000-0002-9481-2557
Anna DevauxDepartment of Biomedicine, Basel University Hospital and University of Basel, Basel, Switzerland.ORCID 0000-0002-5114-9337
Astrid BeerlageDepartment of Biomedicine, Basel University Hospital and University of Basel, Basel, Switzerland.ORCID 0000-0002-0143-544X
Denis SeyresDepartment of Biomedicine, Basel University Hospital and University of Basel, Basel, Switzerland.ORCID 0000-0002-2066-6980
Alessandro Dell' AglioDepartment of Biomedicine, Basel University Hospital and University of Basel, Basel, Switzerland.
Darius JuskeviciusDepartment of Laboratory Medicine, Diagnostic Hematology, Basel University Hospital, Basel, Switzerland.
Jessica ZuinDepartment of Biomedicine, Basel University Hospital and University of Basel, Basel, Switzerland.ORCID 0000-0003-3253-1984
Thomas BurgoldDepartment of Biomedicine, Basel University Hospital and University of Basel, Basel, Switzerland.ORCID 0009-0006-8324-8934
Sisi WangDivision of Hematology, Department of Oncology, Geneva University Hospitals, Geneva, Switzerland.
Varun KattaDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-4565-7335
Garret ManquenDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0009-0001-2131-1874
Yichao LiDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-5791-096X
Clément LarrueTranslational Research Center for Oncohematology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Anna CamusCimeio Therapeutics, Basel, Switzerland.ORCID 0000-0003-2356-5242
Izabela DurzynskaRidgeline Discovery, Basel, Switzerland.
Lisa C WellingerRidgeline Discovery, Basel, Switzerland.
Ian KirbyADC Therapeutics (UK), London, UK.
Patrick H Van BerkelADC Therapeutics (UK), London, UK.ORCID 0000-0002-7315-0347
Christian KunzRidgeline Discovery, Basel, Switzerland.
Jérôme TamburiniTranslational Research Center for Oncohematology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Francesco BertoniInstitute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland.ORCID 0000-0001-5637-8983
Corinne C WidmerDepartment of Hematology, Basel University Hospital, Basel, Switzerland.ORCID 0000-0001-6354-0774
Shengdar Q TsaiDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-9161-3993
Federico SimonettaDivision of Hematology, Department of Oncology, Geneva University Hospitals, Geneva, Switzerland.
Stefanie UrlingerCimeio Therapeutics, Basel, Switzerland.
Lukas T JekerDepartment of Biomedicine, Basel University Hospital and University of Basel, Basel, Switzerland. lukas.jeker@unibas.ch.ORCID 0000-0002-3359-8796

Funding

Ultra-sensitive, unbiased, high-throughput, biochemical CHANGE-seq genome-wide activity and gRNA sequencing assays for therapeutic genome editing INDsU01AI176471 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI TSAI, SHENGDAR · 2023 to 2025
$1.4M
NIAID NIH HHS U01 AI176471
6 · The paper itself

Abstract

Haematopoietic stem cell (HSC) transplantation (HSCT) is the only curative treatment for a broad range of haematological malignancies, but the standard of care relies on untargeted chemotherapies and limited possibilities to treat malignant cells after HSCT without affecting the transplanted healthy cells

Indexed as

Hematologic NeoplasmsHematopoiesisImmunoconjugatesLeukocyte Common AntigensAnimalsAntibody SpecificityCell Line, TumorFemaleHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHumansMaleMiceImmunoconjugatesLeukocyte Common Antigens

Identifiers

PMID38778101
PMCPMC11186773

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.