Evidence map›Paper›PMID 38778096›Full record

ArticleNature2024

Natural proteome diversity links aneuploidy tolerance to protein turnover.

Julia Muenzner, Pauline Trébulle, Federica Agostini, Henrik Zauber, Christoph B Messner, Martin Steger, Christiane Kilian, Kate Lau, Natalie Barthel, Andrea Lehmann and 13 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Article
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  4. Structural genome variation drives adaptation of the xylose-fermenting yeast Scheffersomyces stipitis to lignocellulosic hydrolysates.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
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  14. Article
  15. Review
  16. Article
  17. Article
  18. Domestication drives repeated evolution of sexual-asexual life cycle trade-offs in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Julia Muenzner *Department of Biochemistry, Charité Universitätsmedizin, Berlin, Germany.ORCID 0000-0002-5402-5890
Pauline Trébulle *Molecular Biology of Metabolism Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0002-4729-5032
Federica AgostiniDepartment of Biochemistry, Charité Universitätsmedizin, Berlin, Germany.ORCID 0000-0002-4255-4867
Henrik ZauberMax Delbrück Center for Molecular Medicine, Berlin, Germany.
Christoph B MessnerMolecular Biology of Metabolism Laboratory, Francis Crick Institute, London, UK.
Martin StegerEvotec (München), Martinsried, Germany.ORCID 0000-0003-1637-8190
Christiane KilianDepartment of Biochemistry, Charité Universitätsmedizin, Berlin, Germany.
Kate LauDepartment of Biochemistry, Charité Universitätsmedizin, Berlin, Germany.
Natalie BarthelDepartment of Biochemistry, Charité Universitätsmedizin, Berlin, Germany.
Andrea LehmannDepartment of Biochemistry, Charité Universitätsmedizin, Berlin, Germany.
Kathrin Textoris-TaubeDepartment of Biochemistry, Charité Universitätsmedizin, Berlin, Germany.
Elodie CaudalUniversité de Strasbourg, CNRS GMGM UMR 7156, Strasbourg, France.
Anna-Sophia EggerMolecular Biology of Metabolism Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0002-5204-7121
Fatma AmariDepartment of Biochemistry, Charité Universitätsmedizin, Berlin, Germany.
Matteo De ChiaraUniversité Côte d'Azur, CNRS, INSERM, IRCAN, Nice, France.ORCID 0000-0003-1014-350X
Vadim DemichevDepartment of Biochemistry, Charité Universitätsmedizin, Berlin, Germany.ORCID 0000-0002-2424-9412
Toni I GossmannComputational Systems Biology, Faculty of Biochemical and Chemical Engineering, TU Dortmund University, Dortmund, Germany.
Michael MüllederCore Facility High-Throughput Mass Spectrometry, Charité Universitätsmedizin, Berlin, Germany.ORCID 0000-0001-9792-3861
Gianni LitiUniversité Côte d'Azur, CNRS, INSERM, IRCAN, Nice, France.ORCID 0000-0002-2318-0775
Joseph SchachererUniversité de Strasbourg, CNRS GMGM UMR 7156, Strasbourg, France.ORCID 0000-0002-6606-6884
Matthias SelbachMax Delbrück Center for Molecular Medicine, Berlin, Germany.ORCID 0000-0003-2454-8751
Judith BermanShmunis School of Biomedical and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel. jberman@tauex.tau.ac.il.ORCID 0000-0002-8577-0084
Markus RalserDepartment of Biochemistry, Charité Universitätsmedizin, Berlin, Germany. markus.ralser@charite.de.ORCID 0000-0001-9535-7413

Funding

European Research CouncilMinistry of Education and ResearchWellcome Trust FC001134
6 · The paper itself

Abstract

Accessing the natural genetic diversity of species unveils hidden genetic traits, clarifies gene functions and allows the generalizability of laboratory findings to be assessed. One notable discovery made in natural isolates of Saccharomyces cerevisiae is that aneuploidy-an imbalance in chromosome copy numbers-is frequent

Indexed as

AneuploidyProteasome Endopeptidase ComplexProteolysisProteomeSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDosage Compensation, GeneticGene Expression ProfilingGenetic VariationGenomicsProteomicsUbiquitinationProteasome Endopeptidase ComplexProteomeSaccharomyces cerevisiae Proteins

Identifiers

PMID38778096
PMCPMC11153158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.