Evidence map›Paper›PMID 38778087›Full record

ArticleNature communications2024

Drug screening on digital microfluidics for cancer precision medicine.

Jiao Zhai, Yingying Liu, Weiqing Ji, Xinru Huang, Ping Wang, Yunyi Li, Haoran Li, Ada Hang-Heng Wong, Xiong Zhou, Ping Chen and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Jiao Zhai *State Key Laboratory of Analog and Mixed-Signal VLSI, Institute of Microelectronics, University of Macau, Macau SAR, China.
Yingying Liu *State Key Laboratory of Analog and Mixed-Signal VLSI, Institute of Microelectronics, University of Macau, Macau SAR, China.
Weiqing Ji *School of Computer and Communication Engineering, University of Science and Technology Beijing, Beijing, China.
Xinru HuangLiver Transplantation Center, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Ping WangDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yunyi LiState Key Laboratory of Analog and Mixed-Signal VLSI, Institute of Microelectronics, University of Macau, Macau SAR, China.
Haoran LiState Key Laboratory of Analog and Mixed-Signal VLSI, Institute of Microelectronics, University of Macau, Macau SAR, China.ORCID http://orcid.org/0000-0002-9080-1797
Ada Hang-Heng WongMoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR, China.ORCID http://orcid.org/0000-0002-5960-9940
Xiong ZhouState Key Laboratory of Analog and Mixed-Signal VLSI, Institute of Microelectronics, University of Macau, Macau SAR, China.
Ping ChenCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Lianhong WangCollege of electrical and information engineering, Hunan University, Changsha, China.
Ning YangState Key Laboratory of Analog and Mixed-Signal VLSI, Institute of Microelectronics, University of Macau, Macau SAR, China.
Chi ChenLiver Transplantation Center, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Haitian ChenLiver Transplantation Center, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.ORCID http://orcid.org/0000-0002-3292-5521
Pui-In MakState Key Laboratory of Analog and Mixed-Signal VLSI, Institute of Microelectronics, University of Macau, Macau SAR, China.
Chu-Xia DengCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China.ORCID http://orcid.org/0000-0001-8033-3902
Rui MartinsState Key Laboratory of Analog and Mixed-Signal VLSI, Institute of Microelectronics, University of Macau, Macau SAR, China.
Mengsu YangDepartment of Biomedical Sciences, and Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong SAR, China.ORCID http://orcid.org/0000-0003-2083-2296
Tsung-Yi HoDepartment of Compute Science and Engineering, The Chinese University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0001-7348-5625
Shuhong YiLiver Transplantation Center, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. yishuhong@163.com.ORCID http://orcid.org/0000-0003-1837-7837
Hailong YaoSchool of Computer and Communication Engineering, University of Science and Technology Beijing, Beijing, China. hailongyao@ustb.edu.cn.ORCID http://orcid.org/0000-0002-8750-3086
Yanwei JiaState Key Laboratory of Analog and Mixed-Signal VLSI, Institute of Microelectronics, University of Macau, Macau SAR, China. yanweijia@um.edu.mo.ORCID http://orcid.org/0000-0001-5795-7450

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug screening based on in-vitro primary tumor cell culture has demonstrated potential in personalized cancer diagnosis. However, the limited number of tumor cells, especially from patients with early stage cancer, has hindered the widespread application of this technique. Hence, we developed a digital microfluidic system for drug screening using primary tumor cells and established a working protocol for precision medicine. Smart control logic was developed to increase the throughput of the system and decrease its footprint to parallelly screen three drugs on a 4 × 4 cm

Indexed as

Breast NeoplasmsMicrofluidicsPrecision MedicineXenograft Model Antitumor AssaysAnimalsAntineoplastic AgentsCell Line, TumorDrug Screening Assays, AntitumorFemaleHumansLab-On-A-Chip DevicesLiver NeoplasmsMiceMicrofluidic Analytical TechniquesAntineoplastic Agents

Identifiers

PMID38778087
PMCPMC11111680

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.