ReviewEuropean journal of ageing2024
Association between chronic pain and dementia: a systematic review and meta-analysis.
Review in European journal of ageing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Chronic Pain and the Risk of Dementia: A Systematic Review and Meta-Analysis.Current pain and headache reports · 2026Pooled it
- A systematic review of brain health in adults with chronic pain.Anaesthesia · 2026Pooled it
- Orofacial pain and dementia: a brief narrative review of associations, putative mechanisms, and relevant clinical considerations.Odontology · 2026Review
- Fibromyalgia and Risk of Alzheimer's DiseaseRelated Dementia: A Nationwide Bidirectional Case-Control Study.Geriatrics (Basel, Switzerland) · 2026Article
- Pain and Nutrition in Dementia and Alzheimer's Phase 1: a cross-sectional, observational study design.Frontiers in dementia · 2026Article
- Sex-specific trajectories and variability of pain burden in relation to cognitive decline and depressive symptoms in older adults: a prospective cohort study from health and retirement study.BMC public health · 2025Article
- The Silent Cognitive Burden of Chronic Pain: Protocol for an AI-Enhanced Living Dose-Response Bayesian Meta-Analysis.Journal of clinical medicine · 2025Article
- Management of Chronic Pain in Elderly Patients: The Central Role of Nurses in Multidisciplinary Care.Geriatrics (Basel, Switzerland) · 2025Review
- The role of the hippocampus and SLC39A8 in chronic musculoskeletal pain-induced dementia: a Mendelian randomization study.Scientific reports · 2025Article
- Correlates of neurocognitive performance in older adults with chronic pain and negative emotions: baseline data from the problem adaptation therapy for pain (PATH-pain) randomized controlled trial.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDementia and chronic pain (CP) are prevalent among older adults. However, no study has systematically reviewed the association between dementia and CP. Therefore, we performed this study to gather evidence about the potential relationship between the two.
methodsTwo authors independently searched PubMed, Embase, and Web of Science to identify all records published up to 1 September 2022 that explored the association between CP and dementia. The methodological quality of the studies was assessed using the Newcastle Ottawa Scale (NOS). A fixed or random-effects model was used to pool the risk estimates.
resultsAmong the initial 3296 articles retrieved, 19 were included in the review (1 cross-sectional, and 18 cohort). The pooled result showed the risk of dementia was 1.42 times higher in CP patients (HR = 1.42, 95% CI 1.23-1.64, P < 0.001). dementia and CP subtypes, gender, and age did not significantly affect the results.
conclusionOur study shows that people who suffered from CP are at an increased risk of developing dementia, regardless of gender, age, and dementia and CP subtypes.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.