Evidence map›Paper›PMID 38777944›Full record

ArticleObesity surgery2024

Vertical Sleeve Gastrectomy Reduces Gut Luminal Deoxycholic Acid Concentrations in Mice.

Rahaf Shishani, Annie Wang, Victoria Lyo, Renu Nandakumar, Bethany P Cummings

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rahaf ShishaniDepartment of Surgery, Division of Foregut, Metabolic, and General Surgery, Center for Alimentary and Metabolic Sciences, School of Medicine, University of California - Davis, Sacramento, CA, 95817, USA.
Annie WangDepartment of Surgery, Division of Foregut, Metabolic, and General Surgery, Center for Alimentary and Metabolic Sciences, School of Medicine, University of California - Davis, Sacramento, CA, 95817, USA.
Victoria LyoDepartment of Surgery, Division of Foregut, Metabolic, and General Surgery, Center for Alimentary and Metabolic Sciences, School of Medicine, University of California - Davis, Sacramento, CA, 95817, USA.
Renu NandakumarBiomarkers Core Laboratory, Irving Institute for Clinical and Translational Research, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA.
Bethany P CummingsDepartment of Surgery, Division of Foregut, Metabolic, and General Surgery, Center for Alimentary and Metabolic Sciences, School of Medicine, University of California - Davis, Sacramento, CA, 95817, USA. bpcummings@ucdavis.edu.ORCID 0000-0003-0627-0151

Funding

Building Interdisciplinary Research Careers in Womens Health at UC Davis - Administrative SupplementK12HD051958 · NICHD · UNIVERSITY OF CALIFORNIA DAVIS · PI LANE, NANCY E · 2005 to 2023
$9.6M
Building Interdisciplinary Research Careers in Women's Health at UC DavisK12AR084220 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Nancy E Lane · 2023 to 2026
$3.0M
Training Program in PharmacologyT32GM144303 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, JOHANNES W HELL · 2022 to 2026
$2.1M
Mapping bile acid metabolism across the gut microbiome in response to dietary fiberR21AT010956 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CUMMINGS, BETHANY PAIGE · 2021 to 2022
$572k
NCCIH NIH HHS R21 AT010956NIAMS NIH HHS K12 AR084220NICHD NIH HHS K12 HD051958NIGMS NIH HHS T32 GM144303NIH HHS R21AT010956
6 · The paper itself

Abstract

backgroundBariatric surgery alters bile acid metabolism, which contributes to post-operative improvements in metabolic health. However, the mechanisms by which bariatric surgery alters bile acid metabolism are incompletely defined. In particular, the role of the gut microbiome in the effects of bariatric surgery on bile acid metabolism is incompletely understood. Therefore, we sought to define the changes in gut luminal bile acid composition after vertical sleeve gastrectomy (VSG).

methodsBile acid profile was determined by UPLC-MS/MS in serum and gut luminal samples from VSG and sham-operated mice. Sham-operated mice were divided into two groups: one was fed ad libitum, while the other was food-restricted to match their body weight to the VSG-operated mice.

resultsVSG decreased gut luminal secondary bile acids, which was driven by a decrease in gut luminal deoxycholic acid concentrations and abundance. However, gut luminal cholic acid (precursor for deoxycholic acid) concentration and abundance did not differ between groups. Therefore, the observed decrease in gut luminal deoxycholic acid abundance after VSG was not due to a reduction in substrate availability.

conclusionVSG decreased gut luminal deoxycholic acid abundance independently of body weight, which may be driven by a decrease in gut bacterial bile acid metabolism.

Indexed as

Deoxycholic AcidGastrectomyGastrointestinal MicrobiomeAnimalsBariatric SurgeryBile Acids and SaltsMaleMiceMice, Inbred C57BLBile Acids and SaltsDeoxycholic AcidBile acidsDeoxycholic acidVertical sleeve gastrectomy

Identifiers

PMID38777944
PMCPMC11217124

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.