Evidence map›Paper›PMID 38777883›Full record

ArticlePediatric radiology2024

Assessment of MR blood-oxygen-level-dependent (BOLD) cerebrovascular reactivity under general anesthesia in children with moyamoya.

Eun Jung Choi, David Levin, Amanda Robertson, Fenella J Kirkham, Prakash Muthusami, Pradeep Krishnan, Manohar Shroff, Mahendranath Moharir, Peter Dirks, Daune MacGregor and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Eun Jung ChoiNeurosciences and Mental Health Program, The Hospital for Sick Children, Toronto, Canada.
David LevinDepartment of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Canada.
Amanda RobertsonNeurosciences and Mental Health Program, The Hospital for Sick Children, Toronto, Canada.
Fenella J KirkhamDevelopmental Neurosciences and Biomedical Research Centre, University College London Great Ormond Street Institute of Child Health, London, UK.
Prakash MuthusamiDiagnostic Imaging and Interventional Radiology, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
Pradeep KrishnanDiagnostic Imaging and Interventional Radiology, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
Manohar ShroffDiagnostic Imaging and Interventional Radiology, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
Mahendranath MoharirDivision of Neurology, The Hospital for Sick Children, Toronto, Canada.
Peter DirksDepartment of Neurosurgery, The Hospital for Sick Children, Toronto, Canada.
Daune MacGregorDivision of Neurology, The Hospital for Sick Children, Toronto, Canada.
Elizabeth PulcineDivision of Neurology, The Hospital for Sick Children, Toronto, Canada.
Ishvinder BhathalDivision of Neurology, The Hospital for Sick Children, Toronto, Canada.
Andrea KassnerStroke Imaging Lab for Children, Peter Gilgan Centre for Research & Learning, Toronto, ON, Canada.
Kirstin WalkerNeurosciences and Mental Health Program, The Hospital for Sick Children, Toronto, Canada.
Warwick AllanDepartment of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Canada.
Gabrielle deVeberStroke Imaging Lab for Children, Peter Gilgan Centre for Research & Learning, Toronto, ON, Canada.
William J LoganDivision of Neurology, The Hospital for Sick Children, Toronto, Canada.
Nomazulu DlaminiNeurosciences and Mental Health Program, The Hospital for Sick Children, Toronto, Canada. nomazulu.dlamini@sickkids.ca.ORCID 0000-0001-5927-3132

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMoyamoya is a progressive, non-atherosclerotic cerebral arteriopathy that may present in childhood and currently has no cure. Early diagnosis is critical to prevent a lifelong risk of neurological morbidity. Blood-oxygen-level-dependent (BOLD) MRI cerebrovascular reactivity (CVR) imaging provides a non-invasive, in vivo measure of autoregulatory capacity and cerebrovascular reserve. However, non-compliant or younger children require general anesthesia to achieve BOLD-CVR imaging.

objectiveTo determine the same-day repeatability of BOLD-CVR imaging under general anesthesia in children with moyamoya. MATERIALS AND

methodsTwenty-eight examination pairs were included (mean patient age = 7.3 ± 4.0 years). Positive and negatively reacting voxels were averaged over signals and counted over brain tissue and vascular territory. The intraclass correlation coefficient (ICC), Wilcoxon signed-rank test, and Bland-Altman plots were used to assess the variability between the scans.

resultsThere was excellent-to-good (≥ 0.59) within-day repeatability in 18 out of 28 paired studies (64.3%). Wilcoxon signed-rank tests demonstrated no significant difference in the grey and white matter CVR estimates, between repeat scans (all p-values > 0.05). Bland-Altman plots of differences in mean magnitude of positive and negative and fractional positive and negative CVR estimates illustrated a reasonable degree of agreement between repeat scans and no systematic bias.

conclusionBOLD-CVR imaging provides repeatable assessment of cerebrovascular reserve in children with moyamoya imaged under general anesthesia.

Indexed as

Anesthesia, GeneralCerebrovascular CirculationMagnetic Resonance ImagingMoyamoya DiseaseAdolescentChildChild, PreschoolFemaleHumansMaleOxygenReproducibility of ResultsOxygenCerebrovascular reactivityFunctional magnetic resonance imagingGeneral anesthesiaMoyamoyaRepeatability

Identifiers

PMID38777883

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.