ArticleNature metabolism2024
Interaction between the gut microbiota and colonic enteroendocrine cells regulates host metabolism.
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Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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27citing papers in PubMed, 1 pooled it
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Beyond bacteria: a multi-omics view of the gut-brain axis in Parkinson's disease.Frontiers in cellular and infection microbiology · 2026Pooled it
- Integrated transcriptomic and metabolomic analyses reveal host-metabolite interactions underlying cloacal inflammation in laying Pekin ducks.Animal bioscience · 2026Article
- Empirical evidence for gut microbial influence on human brain neurochemistry via the gut-brain axis.Molecular psychiatry · 2026Article
- Elucidation of the mechanism by which manganese-iron Prussian blue nanozymes alleviate ischemic stroke damage in a mouse model.Neural regeneration research · 2026Article
- Gut-liver metabolic and enterohormonal remodeling drives progression from metabolic dysfunction-associated steatotic liver disease to steatohepatitis.Metabolism: clinical and experimental · 2026Article
- Gut microbiota in health and disease.Molecular biomedicine · 2026Review
- Multi-omics profiling of gut-serum axis dynamics in gestational sows with different reproductive performance.Microbiology spectrum · 2026Article
- Neuron-tumor interplay in colorectal cancer: from mechanisms of onset and progression to targeted therapies.Cell communication and signaling : CCS · 2026Review
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- Muribaculum intestinale alleviates depressive-like behaviors by inhibiting Th17 cell differentiation and M1 microglia polarization.Microbiome · 2026Article
- Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation.Nature genetics · 2026Article
- The Gut-Brain Axis in Obesity: Mechanisms, Development, and Therapeutic Perspectives.Current nutrition reports · 2026Review
- Gut microbiomes-host immune response and organ dysfunction across the gut-lung, gut-brain, and gut-liver axes.Frontiers in cellular and infection microbiology · 2026Review
- Microbiota shape the colon epithelium controlling inter-crypt absorptive goblet cells via butyrate-GP R109A signalling.Gut microbes · 2025Article
- Inflammation in Diabetic Kidney Disease Is Linked to Gut Dysbiosis and Metabolite Imbalance.Journal of diabetes · 2025Article
- Integrated multi-omics highlights alterations of gut microbiome functions in prodromal and idiopathic Parkinson's disease.Microbiome · 2025Article
- Emerging Nanotechnology Strategies for Obesity Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- An adeno-associated virus gene therapy strategy for anti-obesity treatment by nanocarrier-based delivery systems.Journal of nanobiotechnology · 2025Article
- Microbiota-neuroepithelial signalling across the gut-brain axis.Nature reviews. Microbiology · 2025Review
- Monosodium glutamate: A hidden risk factor for obesity?Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
Corrections and comments
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Authors and funding
25 authors.
Shuai TanDepartment of Endocrinology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, P. R. China. shuaitan_cqmu@163.com.ORCID http://orcid.org/0000-0003-4268-6429
Jacobo L SantolayaDepartment of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Tiffany Freeney WrightDepartment of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Qi LiuDivision of Digestive and Liver Diseases, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Teppei FujikawaCenter for Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sensen ChiDepartment of Immunology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.
Colin P BergstromDivision of Digestive and Liver Diseases, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-3271-0915
Adam LopezDivision of Digestive and Liver Diseases, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Qing ChenDivision of Digestive and Liver Diseases, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Goncalo ValeDepartment of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-1104-0289
Jeffrey G McDonaldDepartment of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-1570-4142
Andrew SchmidtDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0009-0004-2355-9322
Nguyen VoDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-4763-417X
Jiwoong KimQuantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-0220-9329
Hamid BaniasadiDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Li LiDepartment of Endocrinology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, P. R. China.
Gaohui ZhuDepartment of Endocrinology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, P. R. China.
Tong-Chuan HeMolecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, USA.
Xiaowei ZhanQuantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yuuki ObataDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-5461-3521
Aishun JinDepartment of Immunology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.
Da JiaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0002-2205-1998
Joel K ElmquistCenter for Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Luis Sifuentes-DominguezDepartment of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX, USA. luis.sifuentes-dominguez@utsouthwestern.edu.ORCID http://orcid.org/0000-0002-9525-071X
Ezra BursteinDivision of Digestive and Liver Diseases, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA. ezra.burstein@utsouthwestern.edu.ORCID http://orcid.org/0000-0003-4341-6367
Funding
UT Southwestern Center for Translational MedicineUL1TR003163 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2021 to 2025
$39.3MTissue Culture & Antibody Production CoreP01HL160487 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Helen Haskell Hobbs · 2022 to 2026
$14.9MVentromedial Hypothalamic Regulation of Metabolic Changes Induced by ExerciseP01DK119130 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GAUTRON, LAURENT · 2019 to 2023
$10.0MMicrobial Regulation of Retinol Transport and its Role in Intestinal ImmunityR01DK070855 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI LORA V HOOPER · 2005 to 2026
$7.9MUT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff G McDonald · 2022 to 2026
$7.4MUT GASTROENTEROLOGY/HEPATOLOGY RESEARCH TRAINING PROGRAMT32DK007745 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Rodney E Infante · 1997 to 2026
$6.8MMetabolic Benefits of Leptin ReductionR01DK127274 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JOEL K. ELMQUIST, PHILIPP E SCHERER · 2021 to 2026
$5.1MSF1 neurons and sympathetic regulation of glucose homeostasisR01DK100659 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JOEL K. ELMQUIST · 2014 to 2026
$4.8MRegulation of Nutrient Homeostasis by COMMD proteinsR01DK107733 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI DANIEL D BILLADEAU, Ezra Burstein · 2016 to 2026
$4.6MMethods to unveil sex-specific genetic architecture in trans-ancestry meta-analysisR01HG011035 · NHGRI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Bibo Jiang · 2022 to 2026
$3.8MRole of colonic enteroendocrine cells in metabolic controlR01DK130957 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BURSTEIN, EZRA · 2022 to 2025
$2.3MAntibiotic Resistance Determination Utilizing Machine LearningU01AI169298 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI GREENBERG, DAVID ELIHU, ZHAN, XIAOWEI · 2022 to 2024
$1.4MNational Natural Science Foundation of China (National Science Foundation of China) 92254302NCATS NIH HHS UL1 TR003163NHGRI NIH HHS R01 HG011035NHLBI NIH HHS P01 HL160487NIAID NIH HHS U01 AI169298NIDDK NIH HHS K08 DK127197NIDDK NIH HHS P01 DK119130NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK070855NIDDK NIH HHS R01 DK100659NIDDK NIH HHS R01 DK107733NIDDK NIH HHS R01 DK127274NIDDK NIH HHS R01 DK130957NIDDK NIH HHS T32 DK007745Pew Charitable Trusts Pew Scholars Program in Biomedical ScienceU.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR003163U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) P01HL160487U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) R01HG011035U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U01AI169298U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) K08DK127197U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) P01DK119130U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK100659U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK107733U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK127274U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK130957U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) T32DK007745
Abstract
Nutrient handling is an essential function of the gastrointestinal tract. Hormonal responses of small intestinal enteroendocrine cells (EECs) have been extensively studied but much less is known about the role of colonic EECs in metabolic regulation. To address this core question, we investigated a mouse model deficient in colonic EECs. Here we show that colonic EEC deficiency leads to hyperphagia and obesity. Furthermore, colonic EEC deficiency results in altered microbiota composition and metabolism, which we found through antibiotic treatment, germ-free rederivation and transfer to germ-free recipients, to be both necessary and sufficient for the development of obesity. Moreover, studying stool and blood metabolomes, we show that differential glutamate production by intestinal microbiota corresponds to increased appetite and that colonic glutamate administration can directly increase food intake. These observations shed light on an unanticipated host-microbiota axis in the colon, part of a larger gut-brain axis, that regulates host metabolism and body weight.
Indexed as
ColonEnteroendocrine CellsGastrointestinal MicrobiomeObesityAnimalsBrain-Gut AxisGlutamic AcidHyperphagiaMiceMice, Inbred C57BLGlutamic Acid
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.