Evidence map›Paper›PMID 38777849›Full record

ArticleCell death & disease2024

The β-arrestin1/endothelin axis bolsters ovarian fibroblast-dependent invadosome activity and cancer cell metastatic potential.

Danila Del Rio, Ilenia Masi, Valentina Caprara, Flavia Ottavi, Gabriele Albertini Petroni, Erica Salvati, Daniela Trisciuoglio, Sara Maria Giannitelli, Anna Bagnato, Emanuele Mauri and 2 more

Abstract read
In one paragraph

Article in Cell death & disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. GPCR Biased Signaling in Cancer.Handbook of experimental pharmacology · 2026
    Review
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  5. Article
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  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Danila Del Rio *Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, 00185, Italy.
Ilenia Masi *Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, 00185, Italy.ORCID 0000-0001-8927-1998
Valentina CapraraUnit of Preclinical Models and New Therapeutic Agents, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.
Flavia OttaviInstitute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, 00185, Italy.
Gabriele Albertini PetroniInstitute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, 00185, Italy.ORCID 0009-0009-2388-8886
Erica SalvatiInstitute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, 00185, Italy.ORCID 0000-0002-3373-7442
Daniela TrisciuoglioInstitute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, 00185, Italy.ORCID 0000-0002-7007-7914
Sara Maria GiannitelliDepartment of Science and Technology for Sustainable Development and One Health, University Campus Bio-Medico di Roma, Rome, 00128, Italy.ORCID 0000-0002-3616-5953
Anna BagnatoUnit of Preclinical Models and New Therapeutic Agents, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.ORCID 0000-0002-7269-9522
Emanuele MauriDepartment of Chemistry Materials and Chemical Engineering, University Politecnico di Milano, 20133, Milano, Italy.
Francesca SpadaroConfocal Microscopy Unit, Core Facilities, Istituto Superiore di Sanità, Rome, 00161, Italy.ORCID 0000-0002-6610-350X
Laura RosanòInstitute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, 00185, Italy. laura.rosano@cnr.it.ORCID 0000-0002-9962-6411

Funding

Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) 21372
6 · The paper itself

Abstract

Recruitment of fibroblasts to tumors and their activation into cancer-associated fibroblasts (CAFs) is a strategy used by tumor cells to direct extracellular matrix (ECM) remodeling, invasion, and metastasis, highlighting the need to investigate the molecular mechanisms driving CAF function. Endothelin-1 (ET-1) regulates the communication between cancer and stroma and facilitates the progression of serous ovarian cancer (SOC). By binding to Endothelin A (ET

Indexed as

beta-Arrestin 1Cancer-Associated FibroblastsOvarian NeoplasmsPodosomesAnimalsCell Line, TumorCell MovementCell ProliferationEndothelin-1Extracellular MatrixFemaleFibroblastsHumansNeoplasm InvasivenessNeoplasm MetastasisReceptor, Endothelin AARRB1 protein, humanbeta-Arrestin 1Endothelin-1Receptor, Endothelin A

Identifiers

PMID38777849
PMCPMC11111729

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.