Evidence map›Paper›PMID 38777821›Full record

SynthesisNature communications2024

Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery.

Ivan V Zelepukin, Konstantin G Shevchenko, Sergey M Deyev

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 1 synthesis or guideline pooled it.

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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ivan V Zelepukin *Department of Medicinal Chemistry, Uppsala University, 751 23, Uppsala, Sweden. ivan.zelepukin@ilk.uu.se.ORCID http://orcid.org/0000-0003-0209-2116
Konstantin G Shevchenko *Department of Chemistry, Boston University, Boston, MA, 02215, USA. ks627@bu.edu.ORCID http://orcid.org/0000-0003-2411-7636
Sergey M DeyevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997, Moscow, Russia.ORCID http://orcid.org/0000-0002-3952-0631

Funding

Russian Science Foundation (RSF) 21-74-30016
6 · The paper itself

Abstract

Rapid uptake of nanoparticles by mononuclear phagocyte system (MPS) significantly hampers their therapeutic efficacy. Temporal MPS blockade is one of the few ways to overcome this barrier - the approach rediscovered many times under different names but never extensively used in clinic. Using meta-analysis of the published data we prove the efficacy of this technique for enhancing particle circulation in blood and their delivery to tumours, describe a century of its evolution and potential combined mechanism behind it. Finally, we discuss future directions of the research focusing on the features essential for successful clinical translation of the method.

Indexed as

Drug Delivery SystemsMononuclear Phagocyte SystemNanoparticlesAnimalsHumansNanoparticle Drug Delivery SystemNeoplasmsNanoparticle Drug Delivery System

Identifiers

PMID38777821
PMCPMC11111695

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.