ArticleNature communications2024
Unveiling unique clinical phenotypes of hip fracture patients and the temporal association with cardiovascular events.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Implants for fixation of intertrochanteric femoral fracture: a systematic review and network meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2025Pooled it
- [Predictive capacity of 30-day mortality using the Nottingham Scale in people aged 65 years or older with hip fracture in Michoacán].Revista medica del Instituto Mexicano del Seguro Social · 2026Observational
- Chronic kidney disease and mortality in fragility fracture patients: revisiting GFR thresholds.European geriatric medicine · 2025Article
- Estimating cardiovascular effects of influenza vaccination in older adults: a target trial emulation using proximal causal inference.EClinicalMedicine · 2025Article
- Trends in statin prescription among osteoporosis patients: A retrospective cohort study using UK primary care data.PLOS global public health · 2025Article
- Anti-PF4/ Heparin Antibodies Early Seroconversion in Hip Fracture Patients Receiving Low Molecular Weight Heparin Prophylaxis: a Pilot Study of 100 Consecutive Patients.The archives of bone and joint surgery · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Cardiovascular events are the leading cause of death among hip fracture patients. This study aims to identify subphenotypes of hip fracture patients and investigate their association with incident cardiovascular events, all-cause mortality, and health service utilisation in Hong Kong and the United Kingdom populations. By the latent class analysis, we show three distinct clusters in the Hong Kong cohort (n = 78,417): Cluster 1 has cerebrovascular and hypertensive diseases, hyperlipidemia, and diabetes; Cluster 2 has congestive heart failure; Cluster 3 consists of relatively healthy patients. Compared to Cluster 3, higher risks of major adverse cardiovascular events are observed in Cluster 1 (hazard ratio 1.97, 95% CI 1.83 to 2.12) and Cluster 2 (hazard ratio 4.06, 95% CI 3.78 to 4.35). Clusters 1 and 2 are also associated with a higher risk of mortality, more unplanned accident and emergency visits and longer hospital stays. Self-controlled case series analysis shows a significantly elevated risk of major adverse cardiovascular events within 60 days post-hip fracture. Similar associations are observed in the United Kingdom cohort (n = 27,948). Pre-existing heart failure is identified as a unique subphenotype associated with poor prognosis after hip fractures.
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Registered trials
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