Evidence map›Paper›PMID 38777381›Full record

ArticleRNA (New York, N.Y.)2024

Magnesium ions mitigate metastable states in the regulatory landscape of mRNA elements.

Erdong Ding, Susmit Narayan Chaudhury, Jigneshkumar Dahyabhai Prajapati, José N Onuchic, Karissa Y Sanbonmatsu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Exploring functional transitions of the 2'-dG riboswitch aptamer.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Erdong DingCenter for Theoretical Biological Physics, Rice University, Houston, Texas 77005, USA.
Susmit Narayan ChaudhuryTheoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.
Jigneshkumar Dahyabhai PrajapatiTheoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.
José N OnuchicCenter for Theoretical Biological Physics, Rice University, Houston, Texas 77005, USA.
Karissa Y SanbonmatsuTheoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA kys@lanl.gov.

Funding

Structure-based Simulation of Riboswitches: Electrostatic EffectsR01GM110310 · NIGMS · TRIAD NATIONAL SECURITY, LLC · PI SANBONMATSU, KARISSA Y · 2015 to 2023
$2.6M
NIGMS NIH HHS R01 GM110310
6 · The paper itself

Abstract

Residing in the 5' untranslated region of the mRNA, the 2'-deoxyguanosine (2'-dG) riboswitch mRNA element adopts an alternative structure upon binding of the 2'-dG molecule, which terminates transcription. RNA conformations are generally strongly affected by positively charged metal ions (especially Mg

Indexed as

MagnesiumMolecular Dynamics SimulationNucleic Acid ConformationRiboswitchRNA, Messenger5' Untranslated RegionsAptamers, NucleotideLigands5' Untranslated RegionsAptamers, NucleotideLigandsMagnesiumRiboswitchRNA, Messengermagnesiummolecular dynamicsmRNA structureriboswitchRNA folding

Identifiers

PMID38777381
PMCPMC11251524

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.