Evidence map›Paper›PMID 38776875›Full record

ArticleCell reports. Medicine2024

Integrated functional genomic screening to bypass TKI resistance in chronic myeloid leukemia.

Tumas Beinortas, Brian J P Huntly

Abstract read
In one paragraph

Article in Cell reports. Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tumas BeinortasDepartment of Haematology, University of Cambridge, Cambridge, UK; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK; Cambridge University Hospitals, Cambridge, UK.
Brian J P HuntlyDepartment of Haematology, University of Cambridge, Cambridge, UK; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK; Cambridge University Hospitals, Cambridge, UK. Electronic address: bjph2@cam.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CML is readily treatable with tyrosine kinase inhibitors (TKIs); however, resistance occurs, with the disease curable in only ∼15%-20% of patients. Using integrated functional genomics, Adnan Awad et al.

Indexed as

Drug Resistance, NeoplasmGenomicsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveProtein Kinase InhibitorsHumansProtein Kinase Inhibitors

Identifiers

PMID38776875
PMCPMC11148797

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.