Evidence map›Paper›PMID 38776401›Full record

ArticleJournal of medicinal chemistry2024

Development of Penicillin-Based Carbonic Anhydrase Inhibitors Targeting Multidrug-Resistant

Alessandro Bonardi, Alessio Nocentini, Simone Giovannuzzi, Niccolò Paoletti, Andrea Ammara, Silvia Bua, Nader S Abutaleb, Abdallah S Abdelsattar, Clemente Capasso, Paola Gratteri and 3 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Drug Design of Carbonic Anhydrase Inhibitors.Sub-cellular biochemistry · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alessandro BonardiNEUROFARBA Department, Pharmaceutical and Nutraceutical Section and Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Via U. Schiff 6, Sesto Fiorentino, Florence 50019, Italy.
Alessio NocentiniNEUROFARBA Department, Pharmaceutical and Nutraceutical Section and Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Via U. Schiff 6, Sesto Fiorentino, Florence 50019, Italy.ORCID 0000-0003-3342-702X
Simone GiovannuzziNEUROFARBA Department, Pharmaceutical and Nutraceutical Section and Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Via U. Schiff 6, Sesto Fiorentino, Florence 50019, Italy.
Niccolò PaolettiNEUROFARBA Department, Pharmaceutical and Nutraceutical Section and Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Via U. Schiff 6, Sesto Fiorentino, Florence 50019, Italy.ORCID 0000-0002-6874-9419
Andrea AmmaraNEUROFARBA Department, Pharmaceutical and Nutraceutical Section and Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Via U. Schiff 6, Sesto Fiorentino, Florence 50019, Italy.ORCID 0000-0001-7364-1499
Silvia BuaResearch Institute of the University of Bucharest (ICUB), Bucharest 050663, Romania.
Nader S AbutalebDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.
Abdallah S AbdelsattarDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.
Clemente CapassoIstituto di Bioscienze e Biorisorse, CNR, Naples 80131, Italy.
Paola GratteriNEUROFARBA Department, Pharmaceutical and Nutraceutical Section and Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Via U. Schiff 6, Sesto Fiorentino, Florence 50019, Italy.ORCID 0000-0002-9137-2509
Daniel P FlahertyBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-8305-0606
Mohamed N SeleemDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.ORCID 0000-0003-0939-0458
Claudiu T SupuranNEUROFARBA Department, Pharmaceutical and Nutraceutical Section and Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Via U. Schiff 6, Sesto Fiorentino, Florence 50019, Italy.ORCID 0000-0003-4262-0323

Funding

Repurposing novel selective drugs for treatment and decolonization of vancomycin resistant enterococciR01AI148523 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Daniel Patrick Flaherty, Mohamed Seleem · 2019 to 2026
$4.2M
Development of novel anti-Neisseria gonorrhoeae therapeutic agentsR01AI153264 · NIAID · PURDUE UNIVERSITY · PI FLAHERTY, DANIEL PATRICK · 2022 to 2025
$3.1M
NIAID NIH HHS R01 AI148523NIAID NIH HHS R01 AI153264
6 · The paper itself

Abstract

The development of antibacterial drugs with new mechanisms of action is crucial in combating the rise of antibiotic-resistant infections. Bacterial carbonic anhydrases (CAs, EC 4.2.1.1) have been validated as promising antibacterial targets against pathogens such as

Indexed as

Anti-Bacterial AgentsCarbonic Anhydrase InhibitorsCarbonic AnhydrasesMicrobial Sensitivity TestsNeisseria gonorrhoeaeDrug Resistance, Multiple, BacterialEscherichia coliHumansMolecular StructurePenicillinsStructure-Activity RelationshipSulfonamidesAnti-Bacterial AgentsCarbonic Anhydrase InhibitorsCarbonic AnhydrasesPenicillinsSulfonamides

Identifiers

PMID38776401
PMCPMC12171872

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.