Evidence map›Paper›PMID 38775966›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

Baseline characteristics and recruitment for SWOG S1820: altering intake, managing bowel symptoms in survivors of rectal cancer (AIMS-RC).

Virginia Sun, Cynthia A Thomson, Tracy E Crane, Kathryn B Arnold, Katherine A Guthrie, Sarah G Freylersythe, Christa Braun-Inglis, Lee Jones, Joseph C Carmichael, Craig Messick and 4 more

Abstract readMulticenter Study
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Virginia SunDepartment of Population Sciences and Department of Surgery, City of Hope, Duarte, CA, 91010, USA. vsun@coh.org.
Cynthia A ThomsonUniversity of Arizona Cancer Center, Tucson, AZ, USA.
Tracy E CraneDivision of Medical Oncology, Miller School of Medicine, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL, USA.
Kathryn B ArnoldSWOG Statistics and Data Management Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Katherine A GuthrieSWOG Statistics and Data Management Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Sarah G FreylersytheDivision of Medical Oncology, Miller School of Medicine, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL, USA.
Christa Braun-InglisUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Lee JonesResearch Advocate, Arlington, VA, USA.
Joseph C CarmichaelDivision of Colon & Rectal Surgery, Department of Surgery, University of California Irvine, Irvine, CA, USA.
Craig MessickDepartment of Colon and Rectum Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Devin FlahertyValleyHealth/Winchester Medical Center, Winchester, VA, USA.
Samir AmbraleUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Stacey A CohenUniversity of Washington and Fred Hutchinson Cancer Center, Seattle, WA, USA.
Robert S KrousePerelman School of Medicine, University of Pennsylvania and the Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.

Funding

SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
Altering Intake and Managing Symptoms in Rectal Cancer Survivors: A Multimodal Diet Modification Intervention for Bowel DysfunctionR21CA236057 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SUN, VIRGINIA CHIH-YI, THOMSON, CYNTHIA A. · 2019 to 2020
$427k
NCI NIH HHS R21 CA236057NCI NIH HHS R21CA236057NCI NIH HHS UG1 CA189974
6 · The paper itself

Abstract

purposeMany survivors of rectal cancer experience persistent bowel dysfunction. There are few evidence-based symptom management interventions to improve bowel control. The purpose of this study is to describe recruitment and pre-randomization baseline sociodemographic, health status, and clinical characteristics for SWOG S1820, a trial of the Altering Intake, Managing Symptoms in Rectal Cancer (AIMS-RC) intervention.

methodsSWOG S1820 aimed to determine the preliminary efficacy, feasibility, and acceptability of AIMS-RC, a symptom management intervention for bowel health, comparing intervention to attention control. Survivors with a history of cancers of the rectosigmoid colon or rectum, within 6-24 months of primary treatment completion, with a post-surgical permanent ostomy or anastomosis, and over 18 years of age were enrolled. Outcomes included total bowel function, low anterior resection syndrome, quality of life, motivation for managing bowel health, self-efficacy for managing symptoms, positive and negative affect, and study feasibility and acceptability.

resultsThe trial completed accrual over a 29-month period and enrolled 117 participants from 34 institutions across 17 states and one US Pacific territory. At baseline, most enrolled participants reported self-imposed diet adjustments after surgery, persistent dietary intolerances, and bowel discomfort post-treatment, with high levels of constipation and diarrhea (grades 1-4).

conclusionsSWOG S1820 was able to recruit, in a timely manner, a study cohort that is demographically representative of US survivors of rectal cancer. Baseline characteristics illustrate the connection between diet/eating and bowel symptoms post-treatment, with many participants reporting diet adjustments and persistent inability to be comfortable with dietary intake. CLINICALTRIALS: GOV REGISTRATION DATE: 12/19/2019. CLINICALTRIALS: GOV IDENTIFIER: NCT#04205955.

Indexed as

Cancer SurvivorsQuality of LifeRectal NeoplasmsAdultAgedFeasibility StudiesFemaleHumansMaleMiddle AgedPatient SelectionSelf EfficacyBowel dysfunctionDiet modificationInterventionQuality of lifeSelf-management

Identifiers

PMID38775966
PMCPMC11111552

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.