Evidence map›Paper›PMID 38775884›Full record

ArticleDrug delivery and translational research2025

Design and development of a soluble PDA-Emodin-PVP-MN patch and its anti-obesity effect in rats.

Haijiao Wang, Lifang Wang, Meng Wang, Jingjing Niu, Bowen Yang, Yinxiong Wang, Min An, Xiuxia Sun, Zhigang Yang, Xuefeng Li and 1 more

Abstract read
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In one paragraph

Article in Drug delivery and translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haijiao WangSchool of Pharmacy & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China.
Lifang WangSchool of Pharmacy & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China.
Meng WangSchool of Pharmacy & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China.
Jingjing NiuSchool of Pharmacy & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China.
Bowen YangSchool of Pharmacy & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China.
Yinxiong WangSchool of Pharmacy & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China.
Min AnSchool of Pharmacy & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China.
Xiuxia SunSchool of Pharmacy & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China.
Zhigang YangSchool of Pharmacy & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China.
Xuefeng LiSchool of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
Yanbin ShiSchool of Pharmacy & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China. shiyb@lzu.edu.cn.ORCID 0000-0001-5333-9866

Funding

Cultivation Project of Medical Student Innovation and Entrepreneurship Competition of Lanzhou University Medical Science Department, China lzuyxcx-2022-104Lanzhou University Innovation and Entrepreneurship Cultivation Program, China cxcy202114Technology Innovation Guide Project of Gansu Province, China 22CX8NA002
6 · The paper itself

Abstract

Emodin has been proven to have weight-reducing and lipid-lowering effects. In order to make emodin play a better anti-obesity role, we designed and developed an emodin loaded dissolving microneedle patch, in which emodin existed in the form of emodin-polyvinylpyrrolidone co-precipitate (Emodin-PVP). Meanwhile, polydopamine (PDA) was added to the microneedle patch (PDA-Emodin-PVP-MN) for photothermal-enhanced chemotherapy of obesity. The average weight of the patch was 0.1 ± 0.05 g and the drug loading was 0.37 ± 0.031 mg. After 5 min of NIR irradiation (808 nm, 0.6 W/cm

Indexed as

Anti-Obesity AgentsEmodinIndolesObesityPolymersPovidoneRats, Sprague-DawleyAnimalsDiet, High-FatDrug LiberationMaleNeedlesRatsSolubilityTransdermal PatchAnti-Obesity AgentsEmodinIndolespolydopaminePolymersPovidoneEmodin-PVP coprecipitateMicroneedlePolydopamineWeight loss effect

Identifiers

PMID38775884

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.