Evidence map›Paper›PMID 38775860›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Reperfusion therapies in patients with acute ischaemic stroke and atrial fibrillation: data on safety and effectiveness from a multi-centre cohort study.

Virginia Cancelloni, Mariachiara Buratti, Georgios Tsivgoulis, Karen L Furie, Prasanna Tadi, Valeria Caso, Cecilia Becattini, Giancarlo Agnelli, Marialuisa Zedde, Azmil H Abdul-Rahim and 73 more

Abstract readMulticenter Study
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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

83 authors.

Virginia CancelloniStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy. virginia.cancelloni@gmail.com.ORCID http://orcid.org/0000-0003-0986-6575
Mariachiara BurattiStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Georgios TsivgoulisSecond Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Attikon" University Hospital, Athens, Greece.
Karen L FurieDivision of Stroke and Cerebrovascular Diseases, Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
Prasanna TadiGeisinger Medical Center, Danville, PA, USA.
Valeria CasoStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Cecilia BecattiniStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Giancarlo AgnelliStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Marialuisa ZeddeNeurology Unit, Stroke Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
Azmil H Abdul-RahimLiverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK.
Andrea AlbertiStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Michele VentiStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Ilaria Leone de MagistrisStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Monica AcciarresiSC Neurologia, San Giovanni Battista Hospital, Foligno, Italy.
Cataldo D'AmoreStroke Unit, Ospedale Di Portogruaro, Portogruaro, Venice, Italy.
Maria G MosconiStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Ludovica A CiminiStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Manuel CappellariSSO Stroke Unit, UO Neurologia, DAI Di Neuroscienze, AOUI, Verona, Italy.
Jukka PutaalaDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Liisa TomppoDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Turgut TatlisumakDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Fabio BandiniSC Neurologia, Villa Scassi Hospital, ASL 3 Genovese, Genoa, Italy.
Simona MarcheselliNeurologia d'Urgenza E Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy.
Alessandro PezziniDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Brescia, Italy.
Sung-I I SohnDeparment of Neurology, Keimyung University School of Medicine, Daegu, South Korea.
Gianni LorenziniSC Di Medicina E Chirurgia d'Accettazione E d'Urgenza, Ospedali Di Pontedera E Volterra, Pontedera E Volterra, Italy.
Rossana TassiStroke Unit, AOU Senese, Siena, Italy.
Francesca GuideriStroke Unit, AOU Senese, Siena, Italy.
Maurizio AcampaStroke Unit, AOU Senese, Siena, Italy.
George NtaiosDepartment of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Efstathia KaragkioziDepartment of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
George AthanasakisDepartment of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Kostantinos MakaritsisDepartment of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Dimitrios SagrisDepartment of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Anastasia AdamouDepartment of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Kostantinos VadikoliasDepartment of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
Lina PalaiodimouSecond Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Attikon" University Hospital, Athens, Greece.
Maria ChondrogianniSecond Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Attikon" University Hospital, Athens, Greece.
Nicola MumoliUOC General Medicine, ASST Ovest Milanese, Legnano Hospital, Legnano, Italy.
Franco GalatiStroke Unit, Jazzolino Hospital, Vibo Valentia, Italy.
Simona SaccoDepartment of Neurology, University of L'Aquila, Avezzano Hospital, Avezzano, Italy.
Cindy TiseoDepartment of Neurology, University of L'Aquila, Avezzano Hospital, Avezzano, Italy.
Francesco CoreaSC Neurologia, San Giovanni Battista Hospital, Foligno, Italy.
Walter AgenoDepartment of Internal Medicine, Insubria University, Varese, Italy.
Marta BellesiniDepartment of Internal Medicine, Insubria University, Varese, Italy.
Giorgio SilvestrelliSC Di Neurologia E SS Di Stroke Unit, ASST Di Mantova, Mantua, Italy.
Alfonso CicconeSC Di Neurologia E SS Di Stroke Unit, ASST Di Mantova, Mantua, Italy.
Michelangelo MancusoClinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy.
Giovanni OrlandiClinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy.
Rosario PascarellaNeuroradiology Unit, Azienda Unità Sanitaria Locale-IRCCS Di Reggio Emilia, Reggio Emilia, Italy.
Tiziana TassinariStroke Unit, Department of Neurology, Santa Corona Hospital, Pietra Ligure, Savona, Italy.
Christina RueckertNeuroscience and Cognition, Utrecht University, Utrecht, Netherlands.
Antonio BaldiStroke Unit, Ospedale Di Portogruaro, Portogruaro, Venice, Italy.
Danilo ToniDepartment of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
Federica LettieriDepartment of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
Martina GiuntiniClinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy.
Enrico M LottiUO Neurologia Presidio Ospedaliero Di Ravenna Azienda USL Della Romagna, Ravenna, Italy.
Yuriy FlominStroke Unit and Neurorehabilitation Unit MC, Universal Clinic 'Oberig', Kiev, Ukraine.
Alessio PieroniUOSD Stroke Unit, Azienda Ospedale Università Padova, Padua, Italy.
Odysseas KargiotisStroke Unit, Metropolitan Hospital, Piraeus, Greece.
Theodore Karapanayiotides2nd Department of Neurology, AHEPA University Hospital, Thessaloniki, Greece.
Panagiotis HalvatsiotisSecond Department of Internal Medicine-Propaedeutic and Diabetes Center, Medical School, University General Hospital "Attikon", National and Kapodistrian University of Athens, Athens, Greece.
Serena MonacoStroke Unit, Ospedale Civico, Palermo, Italy.
Mario M BaronelloStroke Unit, Ospedale Civico, Palermo, Italy.
Laszlò CsibaStroke Unit, University of Debrecen, Debrecen, Hungary.
Lilla SzabòStroke Unit, University of Debrecen, Debrecen, Hungary.
Alberto ChitiNeurologia, Ospedale Apuano, Massa Carrara, Italy.
Elisa GiorliStroke Unit, Department of Neurology, Sant'Andrea Hospital, La Spezia, Italy.
Massimo Del SetteUOC Neurologia, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Davide ImbertiDepartment of Internal Medicine, Ospedale Civile Di Piacenza, Piacenza, Italy.
Dorjan ZabzuniMunicipal Budgetary Healthcare Institution of Novosibirsk, Novosibirsk State Medical University, City Clinical Hospital N°1, Novosibirsk, Russia.
Boris DoroninMunicipal Budgetary Healthcare Institution of Novosibirsk, Novosibirsk State Medical University, City Clinical Hospital N°1, Novosibirsk, Russia.
Vera VolodinaMunicipal Budgetary Healthcare Institution of Novosibirsk, Novosibirsk State Medical University, City Clinical Hospital N°1, Novosibirsk, Russia.
Patrik MichelCentre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Peter VanackerDepartment of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium.
Kristian BarlinnDepartment of Neurology, Dresden University Stroke Center, Dresden, Germany.
Lars P PallesenDepartment of Neurology, Dresden University Stroke Center, Dresden, Germany.
Jessica KepplingerDepartment of Neurology, Dresden University Stroke Center, Dresden, Germany.
Dirk DeleuHamad Medical Corporation, Doha, Qatar.
Vanessa GourbaliDepartment of Neurology, Evangelismo Hospital, Athens, Greece.
Shadi YaghiDivision of Stroke and Cerebrovascular Diseases, Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
Maurizio PaciaroniStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
RAF, R. A. F.-NOACs Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntravenous thrombolysis (IVT) and/or endovascular therapy (EVT) are currently considered best practices in acute stroke patients. Data regarding the efficacy and safety of reperfusion therapies in patients with atrial fibrillation (AF) are conflicting as regards haemorrhagic transformation, mortality, and functional outcome. This study sought to investigate for any differences, in terms of safety and effectiveness, between AF patients with acute ischaemic stroke (AIS) treated and untreated with reperfusion therapies.

methodsData from two multicenter cohort studies (RAF and RAF-NOACs) on consecutive patients with AF and AIS were analyzed to compare patients treated and not treated with reperfusion therapies (IVT and/or EVT). Multivariable logistic regression analysis was performed to identify independent predictors for outcome events: 90-day good functional outcome and mortality. A propensity score matching (PSM) analysis compared treated and untreated patients.

resultsOverall, 441 (25.4%) were included in the reperfusion-treated group and 1,295 (74.6%) in the untreated group. The multivariable model suggested that reperfusion therapies were significantly associated with good functional outcome. Rates of mortality and disability were higher in patients not treated, especially in the case of higher NIHSS scores. In the PSM comparison, 173/250 patients (69.2%) who had received reperfusion therapies had good functional outcome at 90 days, compared to 146/250 (58.4%) untreated patients (p = 0.009, OR: 1.60, 95% CI:1.11-2.31).

conclusionsPatients with AF and AIS treated with reperfusion therapies had a significantly higher rate of good functional outcome and lower rates of mortality compared to those patients with AF and AIS who had undergone conservative treatment.

Indexed as

Atrial FibrillationEndovascular ProceduresIschemic StrokeAgedAged, 80 and overCohort StudiesFemaleHumansMaleMiddle AgedReperfusionThrombolytic TherapyTreatment Outcomeatrial fibrillationendovascular therapyintravenous thrombolysisischaemic strokeoutcomereperfusion therapies

Identifiers

PMID38775860
PMCPMC11422471

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