ArticleThe Journal of antimicrobial chemotherapy2024
Azithromycin resistance in Escherichia coli and Salmonella from food-producing animals and meat in Europe.
Article in The Journal of antimicrobial chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Prevalence and molecular characteristics of colistin-resistant Escherichia coli in livestock and fresh meat detected by a selective enrichment method.Veterinary research communications · 2026Article
- Genomic characterization of multidrug-resistant Salmonella Choleraesuis ST145 isolated from a pig in South Korea and its phylogenomic relationship to global lineages.Veterinary research communications · 2026Article
- Antibiofilm efficacy of phage W5 against antimicrobial-resistantApplied and environmental microbiology · 2026Article
- Alternative Approaches and Plant-Based Remedies for Livestock Health Management Among the Batswana of Southern Africa: A Review.Chemistry & biodiversity · 2026Review
- An update on Escalating Drug Resistance among Uropathogenic Bacteria: Challenges in Treatment and Scope for Maneuver.Current microbiology · 2026Review
- Investigation of the azithromycin resistance rate and related genes involved in this resistance in clinical Shigella species collected from children with diarrhea in Ahvaz, Southwest Iran.Molecular biology reports · 2026Article
- Prevalence and Differential Plasmid Versus Chromosomal Distribution of Ribosome-Targeting Antibiotic Resistance Genes inAntibiotics (Basel, Switzerland) · 2026Article
- Human-associated NDM-5-producing multidrug-resistantFrontiers in bioinformatics · 2026Article
- Phenotypic and genomic analysis of antimicrobial resistantFrontiers in microbiology · 2026Article
- From Widespread Use to Loss of Effectiveness: The Consequences of Inappropriate Azithromycin Prescriptions During the COVID-19 Pandemic-A Systematic Review and Meta-Analysis.International journal of microbiology · 2026Review
- Emergence of carbapenem-resistantMicrobiology spectrum · 2025Article
- Dominance of high-risk clones ST2 and ST571 and the diversity of resistance islands in clinicalMicrobial genomics · 2025Article
- Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Geography, Antimicrobial Resistance, and Genomics ofMicroorganisms · 2024Article
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48 authors.
Funding
Abstract
objectivesTo characterize the genetic basis of azithromycin resistance in Escherichia coli and Salmonella collected within the EU harmonized antimicrobial resistance (AMR) surveillance programme in 2014-18 and the Danish AMR surveillance programme in 2016-19.
methodsWGS data of 1007 E. coli [165 azithromycin resistant (MIC > 16 mg/L)] and 269 Salmonella [29 azithromycin resistant (MIC > 16 mg/L)] were screened for acquired macrolide resistance genes and mutations in rplDV, 23S rRNA and acrB genes using ResFinder v4.0, AMRFinder Plus and custom scripts. Genotype-phenotype concordance was determined for all isolates. Transferability of mef(C)-mph(G)-carrying plasmids was assessed by conjugation experiments.
resultsmph(A), mph(B), mef(B), erm(B) and mef(C)-mph(G) were detected in E. coli and Salmonella, whereas erm(C), erm(42), ere(A) and mph(E)-msr(E) were detected in E. coli only. The presence of macrolide resistance genes, alone or in combination, was concordant with the azithromycin-resistant phenotype in 69% of isolates. Distinct mph(A) operon structures were observed in azithromycin-susceptible (n = 50) and -resistant (n = 136) isolates. mef(C)-mph(G) were detected in porcine and bovine E. coli and in porcine Salmonella enterica serovar Derby and Salmonella enterica 1,4, [5],12:i:-, flanked downstream by ISCR2 or TnAs1 and associated with IncIγ and IncFII plasmids.
conclusionsDiverse azithromycin resistance genes were detected in E. coli and Salmonella from food-producing animals and meat in Europe. Azithromycin resistance genes mef(C)-mph(G) and erm(42) appear to be emerging primarily in porcine E. coli isolates. The identification of distinct mph(A) operon structures in susceptible and resistant isolates increases the predictive power of WGS-based methods for in silico detection of azithromycin resistance in Enterobacterales.
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