Evidence map›Paper›PMID 38774750›Full record

ArticleInternational journal of medical sciences2024

Pyruvate kinase M2 sustains cardiac mitochondrial integrity in septic cardiomyopathy by regulating PHB2-dependent mitochondrial biogenesis.

Jiaxi Ren, Bin Ren, Tong Fu, Yanchun Ma, Ying Tan, Shuxiang Zhang, Yan Li, Qi Wang, Xing Chang, Ying Tong

Abstract read
In one paragraph

Article in International journal of medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. PKM2: A gatekeeper in macrophage metabolic reprogramming.Journal of pharmaceutical analysis · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. p16Journal of cardiovascular translational research · 2025
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiaxi RenLuoyang Branch of Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Luoyang Hospital of TCM, Luoyang 471000, China.
Bin RenDaqing Oilfield General Hospital, Daqing 163000, China.
Tong FuBrandeis University, Waltham, MA 02453, USA.
Yanchun MaHeilongjiang University of Chinese Medicine, Harbin 150040, China.
Ying TanBrandeis University, Waltham, MA 02453, USA.
Shuxiang ZhangHeilongjiang University of Chinese Medicine, Harbin 150040, China.
Yan LiHeilongjiang University of Chinese Medicine, Harbin 150040, China.
Qi WangFirst Afliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Xing ChangGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Ying TongFirst Afliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have highlighted the protective effects of pyruvate kinase M2 (PKM2) overexpression in septic cardiomyopathy. In our study, we utilized cardiomyocyte-specific

Indexed as

CardiomyopathiesMitochondria, HeartOrganelle BiogenesisProhibitinsPyruvate KinaseSepsisAnimalsDisease Models, AnimalHumansLipopolysaccharidesMaleMiceMice, KnockoutMyocytes, CardiacRepressor ProteinsLipopolysaccharidesPhb2 protein, mousePkm protein, mouseProhibitinsPyruvate KinaseRepressor Proteinsmitochondrial biogenesisPHB2PKM2septic cardiomyopathy

Identifiers

PMID38774750
PMCPMC11103386

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.