Evidence map›Paper›PMID 38774565›Full record

ArticleEcancermedicalscience2024

Improving access to cancer clinical research in Brazil: recent advances and new opportunities. Expert opinions from the 4th CURA meeting, São Paulo, 2023.

Heloisa Resende, Roberto J Arai, Carlos H Barrios, Fernanda Schwyter, Nelson L S Teich, Andre Gomes, Analluza B Dallari, Laís A S Bonilha, Claudiosvam M A Souza, Fernando R Francisco and 9 more

Abstract read
In one paragraph

Article in Ecancermedicalscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Heloisa ResendeInstituto Projeto Cura, São Paulo 05507-020, SP, Brazil.
Roberto J AraiIndependent Clinical Researcher, São Paulo 01153-000, SP, Brazil.
Carlos H BarriosLatin American Cooperative Oncology Group (LACOG), Porto Alegre 90619-900, RS, Brazil.
Fernanda SchwyterInstituto Projeto Cura, São Paulo 05507-020, SP, Brazil.
Nelson L S TeichInstituto Teich de Políticas Públicas em Saúde, Rio de Janeiro 22640-102, RJ, Brazil.
Andre GomesBristol Myers Squibb, São Paulo 04719-002, SP, Brazil.
Analluza B DallariIndependent Lawyer, São Paulo 01153-000, SP, Brazil.
Laís A S BonilhaComissão Nacional de Ética em Pesquisa (CONEP), Brasília 70719-040, DF, Brazil.
Claudiosvam M A SouzaAgência Nacional de Vigilância Sanitária - Anvisa, Brasília 71205-050, DF, Brazil.
Fernando R FranciscoAssociação Brasileira de Organizações Representativas de Pesquisa Clínica- Abracro, São Paulo 01311-902, SP, Brazil.
Rodrigo R MunhozHospital Sírio Libanês, São Paulo 01308-050, SP, Brazil.
Gustavo WerutskyLatin American Cooperative Oncology Group (LACOG), Porto Alegre 90619-900, RS, Brazil.
Marisa MadiSociedade Brasileira de Oncologia Clínica (SBOC), São Paulo 01311-300, SP, Brazil.
Paulo FernandesAssociação Brasileira de Organizações Representativas de Pesquisa Clínica- Abracro, São Paulo 01311-902, SP, Brazil.
Jose M FigueiredoInstituto do Câncer Brasil, Taubaté 12030-200, SP, Brazil.
Fabio FedozziAssociação Brasileira de Linfoma e Leucemia, ABRALE, São Paulo 05423-040, SP, Brazil.
Lilian ArrudaHospital São Camilo, São Paulo 05022-001, SP, Brazil.
Vinícius Q AguiarCentro Universitário de Volta Redonda - UNIFOA, Volta Redonda 27240-560, RJ, Brazil.
Andreia C MeloBrazilian National Cancer Institute (INCA), Division of Clinical Research and Technological Development, Rio de Janeiro 20230-130, RJ, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical research is the cornerstone of improvements in cancer care. However, it has been conducted predominantly in high-income countries with few clinical trials available in Brazil and other low-and-middle-income countries (LMIC). Of note, less than one-third of registered clinical trials addressing some of the most commonly diagnosed cancers (breast, lung and cervical) recruited patients from LMIC in the last years. The Institute Project CURA promoted the fourth CURA meeting, discussing barriers to cancer clinical research and proposing potential solutions. A meeting was held in São Paulo, Brazil, in June 2023 with representatives from different sectors: Brazilian Health Regulatory Agency (Anvisa), National Commission of Ethics in Research (CONEP), non-governmental organisations, such as the Latin American Cooperative Oncology Group, the Brazilian Society of Clinical Oncology (SBOC), Contract Research Organisations, pharmaceutical companies and investigators. A total of 16 experts pointed out achievements as shortening the time of regulatory processes involving Anvisa and CONEP, development of staff training programs, maintenance of the National Program of Oncological Attention (PRONON), and the foundation of qualified centres in North and Northeast Brazilian regions. Participants also highlighted the need to be more competitive in the field, which requires optimising ongoing policies and implementing new strategies as decentralisation of clinical research centres, public awareness campaigns, community-centered approaches, collaborations and partnerships, expansion of physicians-directed policies, exploring the role of the steering committee. Active and consistent reporting of the initiatives might help to propagate ongoing advances, increasing Brazilian participation in clinical cancer research. Engagement of all players is crucial to maintain continuous progress with further improvements in critical points including regulatory timelines and increments in qualified human resources which aligned with new educational initiatives focused on physicians and the general population will expand access to cancer clinical trials in Brazil.

Indexed as

cancerclinical trialslow- and middle-income countries

Identifiers

PMID38774565
PMCPMC11108048

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.