Evidence map›Paper›PMID 38774466›Full record

ArticleJU open plus2024

Expert Perspectives on Controversies in Castration-Sensitive Prostate Cancer Management: Narrative Review and Report of the First US Prostate Cancer Conference Part 1.

E David Crawford, Alan H Bryce, Maha H Hussain, Neeraj Agarwal, Himisha Beltran, Matthew R Cooperberg, Daniel P Petrylak, Neal Shore, Daniel E Spratt, Scott T Tagawa and 28 more

Abstract read
In one paragraph

Article in JU open plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

E David CrawfordDepartment of Urology, University of California San Diego, La Jolla, California.
Alan H BryceDivision of Hematology and Medical Oncology, Mayo Clinic, Phoenix, Arizona.
Maha H HussainRobert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois.
Neeraj AgarwalHuntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
Himisha BeltranDepartment of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.
Matthew R CooperbergDepartment of Urology, University of California at San Francisco, San Francisco, California.
Daniel P PetrylakYale New Haven Health, New Haven, Connecticut.
Neal ShoreCarolina Urologic Research Center/Genesis Care, Myrtle Beach, South Carolina.
Daniel E SprattUniversity Hospitals Seidman Cancer Center, Cleveland, Ohio.
Scott T TagawaDivision of Hematology & Medical Oncology, Weill Cornell Medicine, New York, New York.
Emmanuel S AntonarakisMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0003-3531-3851
Ana M AparicioDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0003-0900-0923
Andrew J ArmstrongDuke Cancer Institute Center for Prostate and Urologic Cancers, Durham, North Carolina.
Thomas P BoikeMichigan Healthcare Professionals, Troy, Michigan.
Jeremie CalaisAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California.ORCID 0000-0002-8839-4379
Michael A CarducciHopkins Kimmel Cancer Center, Baltimore, Maryland.
Brian F ChapinDepartment of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Michael S CooksonDepartment of Urology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma.
John W DavisDepartment of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Tanya DorffCity of Hope Comprehensive Cancer Center, Duarte, California.
Scott E EggenerDepartments of Surgery (Urology), University of Chicago Medical Center, Chicago, Illinois.
Felix Y FengDepartments of Radiation Oncology, Urology, and Medicine, University of California San Francisco, San Francisco, California.
Martin GleaveUrological Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.
Celestia HiganoUniversity of British Columbia, Vancouver, British Columbia, Canada.
Andrei IagaruDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, Stanford, California.
Alicia K MorgansDana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Michael MorrisGenitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Katie S MurrayDepartment of Urology, NYU Langone Health, New York, New York.
Wendy PoageProstate Conditions Education Council, Centennial, Colorado.
Matthew B RettigDepartment of Medicine, Division of Hematology-Oncology, VA Greater Los Angeles, Los Angeles, California.
Oliver SartorTulane Cancer Center, New Orleans, Louisiana.
Howard I ScherGenitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-6791-9324
Paul SieberKeystone Urology Specialists, Lancaster, Pennsylvania.
Eric SmallUCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
Sandy SrinivasDivision of Medical Oncology, Stanford University Medical Center, Stanford, California.
Evan Y YuDepartment of Medicine, Division of Hematology & Oncology, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington.
Tian ZhangDivision of Hematology and Oncology, Department of Internal Medicine, Utah Southwestern Medical Center, Dallas, Texas.
Phillip J KooBanner MD Anderson Cancer Center, Phoenix, Arizona.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA077598
6 · The paper itself

Abstract

Purpose: Castration-sensitive prostate cancer (CSPC) is a complex and heterogeneous condition encompassing a range of clinical presentations. As new approaches have expanded management options, clinicians are left with myriad questions and controversies regarding the optimal individualized management of CSPC. Materials and Methods: The US Prostate Cancer Conference (USPCC) multidisciplinary panel was assembled to address the challenges of prostate cancer management. The first annual USPCC meeting included experts in urology, medical oncology, radiation oncology, and nuclear medicine. USPCC co-chairs and session moderators identified key areas of controversy and uncertainty in prostate cancer management and organized the sessions with multidisciplinary presentations and discussion. Throughout the meeting, experts responded to questions prepared by chairs and moderators to identify areas of agreement and controversy. Results: The USPCC panel discussion and question responses for CSPC-related topics are presented. Key advances in CSPC management endorsed by USPCC experts included the development and clinical utilization of gene expression classifiers and artificial intelligence (AI) models for risk stratification and treatment selection in specific patient populations, the use of advanced imaging modalities in patients with clinically localized unfavorable intermediate or high-risk disease and those with biochemical recurrence, recommendations of doublet or triplet therapy for metastatic CSPC (mCSPC), and consideration of prostate and/or metastasis-directed radiation therapy in select patients with mCSPC. Conclusions: CSPC is a diverse disease with many therapeutic options and the potential for adverse outcomes associated with either undertreatment or overtreatment. Future studies are needed to validate and clinically integrate novel technologies, including genomics, AI, and advanced imaging, to optimize outcomes among patients with CSPC.

Indexed as

biomarkersndrogen antagonistsprecision medicineprostatic neoplasmsradiotherapy

Identifiers

PMID38774466
PMCPMC11108024

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.