Evidence map›Paper›PMID 38774310›Full record

ArticleVirus evolution2024

Emergence and dissemination of SARS-CoV-2 XBB.1.5 in New York.

Fabiana Gámbaro, Ralf Duerr, Dacia Dimartino, Christian Marier, Eduardo Iturrate, Mark J Mulligan, Adriana Heguy, Simon Dellicour

Abstract read
In one paragraph

Article in Virus evolution, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fabiana GámbaroSpatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Brussels 1050, Belgium.
Ralf DuerrDepartment of Medicine, Division of Infectious Diseases and Immunology, NYU Grossman School of Medicine, 10016, USA.ORCID https://orcid.org/0000-0001-9569-9237
Dacia DimartinoGenome Technology Center, Office of Science and Research, NYU Langone Health, 10016, USA.
Christian MarierGenome Technology Center, Office of Science and Research, NYU Langone Health, 10016, USA.
Eduardo IturrateVaccine Center, NYU Grossman School of Medicine, New York, NY 10016, USA.
Mark J MulliganDepartment of Medicine, Division of Infectious Diseases and Immunology, NYU Grossman School of Medicine, 10016, USA.
Adriana HeguyGenome Technology Center, Office of Science and Research, NYU Langone Health, 10016, USA.ORCID https://orcid.org/0000-0002-2836-6683
Simon DellicourSpatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Brussels 1050, Belgium.ORCID https://orcid.org/0000-0001-9558-1052

Funding

Establishment of the New York University Vaccine and Treatment Evaluation Unit (NYU VTEU) - DMID 21-0012UM1AI148574 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Angelica Cifuentes Kottkamp, Anoma Nellore · 2020 to 2026
$23.9M
NIAID NIH HHS UM1 AI148574
6 · The paper itself

Abstract

The recombinant SARS-CoV-2 Omicron XBB.1.5 variant was first detected in New York City (NYC) and rapidly became the predominant variant in the area by early 2023. The increased occurrence of circulating variants within the SARS-CoV-2 XBB-sublineage prompted the modification of COVID-19 mRNA vaccines by Moderna and Pfizer-BioNTech. This update, implemented in mid-September 2023, involved the incorporation of a monovalent XBB.1.5 component. Considering that NYC probably played a central role in the emergence of the XBB.1.5 variant, we conducted phylogeographic analysis to investigate the emergence and spread of this variant in the metropolitan area. Our analysis confirms that XBB.1.5 emerged within or near the NYC area and indicates that XBB.1.5 had a diffusion velocity similar to that of the variant Alpha in the same study area. Additionally, the analysis of 2,392 genomes collected in the context of the genomic surveillance program at NYU Langone Health system showed that there was no increased proportion of XBB.1.5, relative to all cocirculating variants, in the boosted compared to unvaccinated individuals. This study provides a comprehensive description of the emergence and dissemination of XBB.1.5.

Indexed as

molecular epidemiologySARS-CoV-2viral phylogeography

Identifiers

PMID38774310
PMCPMC11108082

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.