A novel microfluidic chip integrated with Pt micro-thermometer for temperature measurement at the single-cell level.

Kai Chen, Baihui Liang, Ping Yang, Min Li, Haojun Yuan, Jinlei Wu, Wanlei Gao, Qinghui Jin

Abstract read

In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Gray Wolf Optimization-Long Short-Term Memory Based Temperature Estimation and Closed-Loop Control Method in Microfluidic Chemiluminescence Immunoassay.Micromachines · 2026
Article

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5 · Who and what money

Authors and funding

8 authors.

Kai ChenCollege of Information Science and Engineering, Ningbo University, Ningbo, 315211, Zhejiang, China.

Baihui LiangHealthy & Intelligent Kitchen Engineering Research Center of Zhejiang Province, Ningbo, 315336, Zhejiang, China.

Ping YangCollege of Information Science and Engineering, Ningbo University, Ningbo, 315211, Zhejiang, China.

Min LiCollege of Information Science and Engineering, Ningbo University, Ningbo, 315211, Zhejiang, China.

Haojun YuanCollege of Information Science and Engineering, Ningbo University, Ningbo, 315211, Zhejiang, China.

Jinlei WuCollege of Information Science and Engineering, Ningbo University, Ningbo, 315211, Zhejiang, China.

Wanlei GaoCollege of Information Science and Engineering, Ningbo University, Ningbo, 315211, Zhejiang, China.

Qinghui JinCollege of Information Science and Engineering, Ningbo University, Ningbo, 315211, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noninvasive and sensitive thermometry of a single cell during the normal physiological process is crucial for analyzing fundamental cellular metabolism and applications to cancer treatment. However, current thermometers generally sense the average temperature variation for many cells, thereby failing to obtain real-time and continuous data of an individual cell. In this study, we employed platinum (Pt) electrodes to construct an integrated microfluidic chip as a single-cell thermometer. The single-cell isolation unit in the microchip consisted of a main channel, which was connected to the inlet and outlet of a single-cell capture funnel. A single cell can be trapped in the funnel and the remaining cells can bypass and flow along the main channel to the outlet. The best capture ratio of a single MCF7 cell at a single-cell isolation unit was 90 % under optimal condition. The thermometer in the micro-chip had a temperature resolution of 0.007 °C and showed a good linear relationship in the range of 20-40 °C (R

Indexed as

In-situ temperature detectionMicrofluidic chipPt electrode-based thermometerSingle cell isolationTumor cell analysis

Identifiers

PMID38774078

DOI10.1016/j.heliyon.2024.e30649

PMCPMC11107094

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.