Evidence map›Paper›PMID 38774036›Full record

ArticleAnnual review of statistics and its application2023

Data integration in Bayesian phylogenetics.

Gabriel W Hassler, Andrew Magee, Zhenyu Zhang, Guy Baele, Philippe Lemey, Xiang Ji, Mathieu Fourment, Marc A Suchard

Abstract read
In one paragraph

Article in Annual review of statistics and its application, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Biological causes and impacts of rugged tree landscapes in phylodynamic inference.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Multi-response phylogenetic mixed models: concepts and application.Biological reviews of the Cambridge Philosophical Society · 2025
    Review
  10. Leveraging graphical model techniques to study evolution on phylogenetic networks.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabriel W HasslerDepartment of Computational Medicine, University of California, Los Angeles, USA, 90095.
Andrew MageeDepartment of Biostatistics, University of California, Los Angeles, USA, 90095.
Zhenyu ZhangDepartment of Biostatistics, University of California, Los Angeles, USA, 90095.
Guy BaeleDepartment of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium, 3000.
Philippe LemeyDepartment of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium, 3000.
Xiang JiDepartment of Mathematics, Tulane University, New Orleans, USA, 70118.
Mathieu FourmentAustralian Institute for Microbiology and Infection, University of Technology Sydney, Ultimo NSW, Australia, 2007.
Marc A SuchardDepartment of Computational Medicine, University of California, Los Angeles, USA, 90095.

Funding

Genomics, GPUs, and Next Generation Computational StatisticsR01HG006139 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOBEL, ERIC · 2011 to 2023
$5.1M
Fast and flexible Bayesian phylogenetics via modern machine learningR01AI162611 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MATSEN, FREDERICK ALBERT · 2021 to 2025
$3.8M
Statistical Innovation to Integrate Sequences and Phenotypes for Scalable Phylodynamic InferenceR01AI153044 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Marc A. Suchard · 2021 to 2026
$2.4M
Scalable Inference in Statistical Models of Viral Evolution and Human HealthF31AI154824 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HASSLER, GABRIEL WILLIAM · 2021 to 2022
$64k
NHGRI NIH HHS R01 HG006139NIAID NIH HHS F31 AI154824NIAID NIH HHS R01 AI153044NIAID NIH HHS R01 AI162611Wellcome Trust
6 · The paper itself

Abstract

Researchers studying the evolution of viral pathogens and other organisms increasingly encounter and use large and complex data sets from multiple different sources. Statistical research in Bayesian phylogenetics has risen to this challenge. Researchers use phylogenetics not only to reconstruct the evolutionary history of a group of organisms, but also to understand the processes that guide its evolution and spread through space and time. To this end, it is now the norm to integrate numerous sources of data. For example, epidemiologists studying the spread of a virus through a region incorporate data including genetic sequences (e.g. DNA), time, location (both continuous and discrete) and environmental covariates (e.g. social connectivity between regions) into a coherent statistical model. Evolutionary biologists routinely do the same with genetic sequences, location, time, fossil and modern phenotypes, and ecological covariates. These complex, hierarchical models readily accommodate both discrete and continuous data and have enormous combined discrete/continuous parameter spaces including, at a minimum, phylogenetic tree topologies and branch lengths. The increased size and complexity of these statistical models have spurred advances in computational methods to make them tractable. We discuss both the modeling and computational advances below, as well as unsolved problems and areas of active research.

Indexed as

Bayesian networkscontinuous-time Markov processesGaussian processesphylogenetic comparative methodsphylogeography

Identifiers

PMID38774036
PMCPMC11108065

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.