Evidence map›Paper›PMID 38774001›Full record

ArticleJACC. CardioOncology2024

Artificial Intelligence Electrocardiography to Predict Atrial Fibrillation in Patients With Chronic Lymphocytic Leukemia.

Georgios Christopoulos, Zachi I Attia, Sara J Achenbach, Kari G Rabe, Timothy G Call, Wei Ding, Jose F Leis, Eli Muchtar, Saad S Kenderian, Yucai Wang and 10 more

Abstract read
In one paragraph

Article in JACC. CardioOncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Cardiovascular Safety of Bruton Tyrosine Kinase Inhibitors: From Ibrutinib to Next-Generation Agents.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Georgios ChristopoulosDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Zachi I AttiaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Sara J AchenbachDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Kari G RabeDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Timothy G CallDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Wei DingDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Jose F LeisDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, Arizona, USA.
Eli MuchtarDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Saad S KenderianDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Yucai WangDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Paul J HampelDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Amber B KoehlerDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Neil E KayDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Prashant KapoorDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Susan L SlagerDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Tait D ShanafeltDepartment of Medicine, Stanford University, Palo Alto, California, USA.
Peter A NoseworthyDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Paul A FriedmanDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Joerg HerrmannDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Sameer A ParikhDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.

Funding

TrAstuzumab Cardiomyopathy Therapeutic Intervention with Carvedilol (TACTIC) TrialR01CA233610 · NCI · MAYO CLINIC ROCHESTER · PI HERRMANN, JOERG, RUDDY, KATHRYN JEAN · 2019 to 2024
$4.3M
NCI NIH HHS R01 CA233610
6 · The paper itself

Abstract

Background: The use of an artificial intelligence electrocardiography (AI-ECG) algorithm has demonstrated its reliability in predicting the risk of atrial fibrillation (AF) within the general population. Objectives: This study aimed to determine the effectiveness of the AI-ECG score in identifying patients with chronic lymphocytic leukemia (CLL) who are at high risk of developing AF. Methods: We estimated the probability of AF based on AI-ECG among patients with CLL extracted from the Mayo Clinic CLL database. Additionally, we computed the Mayo Clinic CLL AF risk score and determined its ability to predict AF. Results: Among 754 newly diagnosed patients with CLL, 71.4% were male (median age = 69 years). The median baseline AI-ECG score was 0.02 (range = 0-0.93), with a value ≥0.1 indicating high risk. Over a median follow-up of 5.8 years, the estimated 10-year cumulative risk of AF was 26.1%. Patients with an AI-ECG score of ≥0.1 had a significantly higher risk of AF (HR: 3.9; 95% CI: 2.6-5.7; Conclusions: An AI-ECG algorithm, in conjunction with the Mayo CLL AF risk score, can predict the risk of AF in patients with newly diagnosed CLL. Additional studies are needed to determine the role of AI-ECG in predicting AF risk in CLL patients treated with a Bruton tyrosine kinase inhibitor.

Indexed as

artificial intelligenceatrial fibrillationchronic lymphocytic leukemiaelectrocardiography

Identifiers

PMID38774001
PMCPMC11103028

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.