Evidence map›Paper›PMID 38773938›Full record

ArticleESC heart failure2024

In vivo fluid dynamics of the Ventura interatrial shunt device in patients with heart failure.

Michael Pfeiffer, John Boehmer, John Gorcsan, Shunsuke Eguchi, Yoshiyuki Orihara, Michal Laufer Perl, Neal Eigler, William T Abraham, Julio Nuñez Villota, Elizabeth Lee and 10 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07696975 (RELIEVE-HFrEF TRIAL), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07696975 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

RELIEVE-HFrEF TRIAL: REducing Lung congestIon Symptoms Using the v-wavE Shunt in adVancEd Heart Failure With Reduced EF

TypeinterventionalSponsorV-Wave LtdRan2026 to 2031Enrolled250ConditionsHeart Failure and Reduced Ejection Fraction, Heart Failure Chronic, Heart Failure New York Heart Association Class III, Heart Failure CongestiveArmsImplantation of the V-Wave Interatrial shunt, Sham (no implant)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Michael PfeifferDivision of Cardiology, Penn State Heart and Vascular Institute, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.ORCID 0000-0002-6472-7896
John BoehmerDivision of Cardiology, Penn State Heart and Vascular Institute, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
John GorcsanDivision of Cardiology, Penn State Heart and Vascular Institute, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
Shunsuke EguchiDivision of Cardiology, Penn State Heart and Vascular Institute, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
Yoshiyuki OriharaDivision of Cardiology, Penn State Heart and Vascular Institute, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
Michal Laufer PerlDivision of Cardiology, Sammy Ofer Heart Center, Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Israel.
Neal EiglerV-Wave, Agoura Hills, California, and Department of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, California, USA.
William T AbrahamDivision of Cardiovascular Medicine, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Julio Nuñez VillotaDepartment of Cardiology, University of Valencia, Valencia, Spain.
Elizabeth LeeDivision of Cardiology, Rochester General Hospital, Rochester, New York, USA.
Antoni Bayés-GenísDepartment of Cardiology, Germans Trias Heart Institute, Germans Trias University Hospital, Badalona, Spain.
Gil MoravskyDivision of Cardiology, Shamir Medical Center (Assaf HaRofeh), Be'er Ya'akov, Israel.
Saibal KarCardiovascular Institute of Los Robles Health System, Los Robles, California, USA.
Michael R ZileDivision of Cardiology, Medical University of South Carolina, Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, South Carolina, USA.
Richard HolcombIndependent Biostatistician, Minneapolis, Minnesota, USA.
Stefan D AnkerDepartment of Cardiology (CVK) of German Heart Center Charité, Institute of Health Center for Regenerative Therapies (BCRT), German Centre for Cardiovascular Research (DZHK) partner site Berlin, Charité University, Berlin, Germany.
Gregg W StoneThe Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
Josep Rodés-CabauQuebec Heart & Lung Institute, Laval University, Quebec City, Canada.
JoAnn LindenfeldDivision of Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jeroen J BaxDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

Funding

V-Wave Ltd., Caesarea, Israel
6 · The paper itself

Abstract

aimsInteratrial shunts are under evaluation as a treatment for heart failure (HF); however, their in vivo flow performance has not been quantitatively studied. We aimed to investigate the fluid dynamics properties of the 0.51 cm orifice diameter Ventura shunt and assess its lumen integrity with serial transesophageal echocardiography (TEE). METHODS AND

resultsComputational fluid dynamics (CFD) and bench flow tests were used to establish the flow-pressure relationship of the shunt. Open-label patients from the RELIEVE-HF trial underwent TEE at shunt implant and at 6 and 12 month follow-up. Shunt effective diameter (D

conclusionsWhen implanted in patients with advanced HF, this small interatrial shunt demonstrated predictable and durable patency and performance.

Indexed as

Echocardiography, TransesophagealHeart FailureHydrodynamicsAgedFemaleFollow-Up StudiesHeart AtriaHumansMaleProsthesis DesignFlow dynamicsHeart failureInteratrial shuntTransesophageal echocardiography

Identifiers

PMID38773938
PMCPMC11424381

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.