Evidence map›Paper›PMID 38773691›Full record

ArticleScandinavian journal of immunology2024

Mucosal-associated invariant T cells modulate innate immune cells and inhibit colon cancer growth.

Olivia J Cheng, Eric J Lebish, Owen Jensen, Damian Jacenik, Shubhanshi Trivedi, Jackson G Cacioppo, Jeffrey Aubé, Ellen J Beswick, Daniel T Leung

Abstract read
In one paragraph

Article in Scandinavian journal of immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Eosinophils in solid cancers: sentinels, predictors, and therapeutic allies.Journal of experimental & clinical cancer research : CR · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Acetoacetate suppresses colon cancer via an MR1-MAIT axis.bioRxiv : the preprint server for biology · 2025
    Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Olivia J ChengDivision of Microbiology & Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0002-6298-3319
Eric J LebishDivision of Gastroenterology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0009-0004-2939-491X
Owen JensenDivision of Microbiology & Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0002-6670-4743
Damian JacenikDivision of Gastroenterology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0003-4563-2303
Shubhanshi TrivediDivision of Infectious Disease, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0001-6891-2290
Jackson G CacioppoDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0002-6514-0739
Jeffrey AubéDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0003-1049-5767
Ellen J BeswickDivision of Gastroenterology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0003-3538-3040
Daniel T LeungDivision of Microbiology & Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0001-8401-0801

Funding

Mucosal associated invariant T (MAIT) cells in Vibrio cholerae infection and vaccinationR01AI130378 · NIAID · UNIVERSITY OF UTAH · PI LEUNG, DANIEL TED · 2017 to 2021
$1.8M
G-CSF inhibition as a colorectal cancer therapyR01CA207051 · NCI · UNIVERSITY OF UTAH · PI BESWICK, ELLEN J. · 2016 to 2021
$1.7M
Mentoring patient-oriented researchers in pediatric diarrheaK24AI166087 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Daniel Ted Leung · 2023 to 2026
$688k
MAIT cells as a therapeutic approach for gastrointestinal cancersR21CA280224 · NCI · UNIVERSITY OF UTAH · PI BESWICK, ELLEN J., LEUNG, DANIEL TED · 2024 to 2024
$384k
NCI NIH HHS R01 CA207051NCI NIH HHS R21 CA280224NIAID NIH HHS K24 AI166087NIAID NIH HHS R01 AI130378NIH HHS K24AI166087NIH HHS R01AI130378NIH HHS R01CA207051
6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can be activated by microbial antigens and cytokines and are abundant in mucosal tissues including the colon. MAIT cells have cytotoxic and pro-inflammatory functions and have potentials for use as adoptive cell therapy. However, studies into their anti-cancer activity, including their role in colon cancer, are limited. Using an animal model of colon cancer, we showed that peritumoral injection of in vivo-expanded MAIT cells into RAG1

Indexed as

Colonic NeoplasmsEosinophilsImmunity, InnateMice, KnockoutMucosal-Associated Invariant T CellsAnimalsCell Line, TumorCoculture TechniquesCytokinesDisease Models, AnimalHomeodomain ProteinsHumansMiceMice, Inbred C57BLCytokinesHomeodomain ProteinsRAG-1 proteincolon cancerimmune modulationmucosal‐associated invariant T cellsproinflammatory cytokinestumor immunity

Identifiers

PMID38773691
PMCPMC11315626

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.