ArticleBMC psychiatry2024
U-shaped association between fasting blood glucose and suicide attempts in Chinese patients with first-episode drug-naïve major depressive disorder.
Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- High- and low-frequency accelerated repetitive transcranial magnetic stimulation for major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Resting-state EEG default mode network connectivity and suicidal ideation in depressive disorders: a retrospective cross-sectional study.BMC psychiatry · 2026Article
- Thyroid-stimulating hormone, fasting blood glucose and suicidal ideation in Chinese adolescents with major depressive disorder: a cross-sectional study.Frontiers in psychiatry · 2026Article
- Prevalence and correlates of suicide attempts in working-age, first-episode, drug-naïve major depressive disorder patients.BMC psychiatry · 2025Article
- The Role of Metabolic Disorders and Laboratory Abnormalities in Wound Healing and Recovery in Geriatric and Non-Geriatric Orthopedic Patients in Poland-Prospective Research.Journal of clinical medicine · 2025Article
- Non-linear effects of self-compassion and negative psychological states on nurses' work engagement.Scientific reports · 2025Article
- Association Between Body Mass Index and Comorbid Anxiety in First-Episode and Drug Naïve Patients With Major Depressive Disorder.Depression and anxiety · 2025Article
- Threshold effect of visceral adiposity index on suicidal ideation: a mediation analysis through fasting blood glucose.Frontiers in psychiatry · 2025Article
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13 authors.
Funding
Abstract
backgroundEvidence regarding the relationship between fasting blood glucose (FBG) and suicide attempts (SA) in patients with major depressive disorder (MDD) was limited. Therefore, the objective of this research was to investigate whether FBG was independently related to SA in Chinese patients with first-episode drug-naïve (FEDN) MDD after adjusting for other covariates.
methodsThe present study was a cross-sectional study. A total of 1718 participants (average age: 34.9 ± 12.4 years, 65.8% females) with FEDN MDD were involved in a hospital in China from September 2016 to December 2018. Multiple logistic regression analysis and smooth curve fitting were used to estimate the association between FBG and the risk of SA. The threshold effect was examined by the two-piecewise linear regression model. Interaction and stratified analyses were conducted according to sex, education, marital status, comorbid anxiety, and psychotic symptoms.
resultsThe prevalence of SA in patients with FEDN MDD was 20.1%. The result of fully adjusted binary logistic regression showed FBG was positively associated with the risk of SA (odds ratio (OR) = 1.62, 95% CI: 1.13-2.32). Smoothing plots also revealed a nonlinear relationship between FBG and SA, with the inflection point of FBG being 5.34 mmol/l. The effect sizes and the confidence intervals on the left and right sides of the inflection point were 0.53 (0.32-0.88, P = 0.014) and 1.48 (1.04-2.10, P = 0.030), respectively.
conclusionsA U-shaped relationship between FBG and SA in FEDN MDD patients was found, with the lowest risk of SA at a FBG of 5.34 mmol/l, indicating that both the lower and higher FBG levels may lead to an increased risk of SA.
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