Evidence map›Paper›PMID 38773450›Full record

ReviewMicrobial cell factories2024

Strategies for improving fengycin production: a review.

Ying Yin, Xin Wang, Pengsheng Zhang, Pan Wang, Jianping Wen

Abstract readReview
In one paragraph

Review in Microbial cell factories, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Small non-coding RNAMicrobiology spectrum · 2026
    Article
  4. Article
  5. Article
  6. Biocontrol of mushroom crop mycoparasites by novelbioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Frontiers in microbiology · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Biocontrol Effect ofMicroorganisms · 2025
    Article
  15. Review
  16. Antimicrobial Activity ofInternational journal of molecular sciences · 2025
    Review
  17. Article
  18. Frontiers in microbiology · 2025
    Article
  19. Identification and Bioactivity Analysis of a NovelAntibiotics (Basel, Switzerland) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ying YinKey Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, P. R. China.
Xin WangColl Biol & Pharmaceut Sci, China Three Gorges Univ, Yichang, 443002, P. R. China.
Pengsheng ZhangKey Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, P. R. China.
Pan WangDepartment of Nuclear Medicine, The First Hospital of Shanxi Medical University, Collaborative Innovation Center of Molecular Imaging Precision Medical, Shanxi Medical University, Taiyuan, 030001, China.
Jianping WenKey Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, P. R. China. jpwen@tju.edu.cn.

Funding

National Key Research and Development Program of China No. 2018YFA0902200
6 · The paper itself

Abstract

Fengycin is an important member of the lipopeptide family with a wide range of applications in the agricultural, food, medical and cosmetic industries. However, its commercial application is severely hindered by low productivity and high cost. Therefore, numerous studies have been devoted to improving the production of fengycin. We summarize these studies in this review with the aim of providing a reference and guidance for future researchers. This review begins with an overview of the synthesis mechanism of fengycin via the non-ribosomal peptide synthetases (NRPS), and then delves into the strategies for improving the fengycin production in recent years. These strategies mainly include fermentation optimization and metabolic engineering, and the metabolic engineering encompasses enhancement of precursor supply, application of regulatory factors, promoter engineering, and application of genome-engineering (genome shuffling and genome-scale metabolic network model). Finally, we conclude this review with a prospect of fengycin production.

Indexed as

LipopeptidesMetabolic EngineeringFermentationPeptide SynthasesfengycinLipopeptidesnon-ribosomal peptide synthasePeptide SynthasesFengycinGenetic engineeringLipopeptideNRPSOptimization

Identifiers

PMID38773450
PMCPMC11110267

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.