ArticleBMC neurology2024
Effect of heart rate on poor outcome in stroke patients treated with intra-arterial thrombectomy.
Article in BMC neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Performance of Modified NIHSS and APUA Scores in Predicting in-Hospital Mortality and Functional Outcome in Acute Ischemic Stroke: A Retrospective Cohort Study.Medeniyet medical journal · 2026Article
- Heart rate and clinical outcome after endovascular treatment in patients with anterior versus posterior circulation large vessel occlusion.Therapeutic advances in neurological disorders · 2026Article
- The Roles of Heart Rate Variability in Cerebral Stroke.Neuropsychiatric disease and treatment · 2025Review
- Early heart rate predicts 3-month outcomes in acute ischemic stroke patients receiving intravenous thrombolysis: a machine learning approach.Frontiers in neurology · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
background and purposeThe relationship between heart rate and the prognosis of patients with large vessel occlusion strokes treated with mechanical thrombectomy (MT) is not well established. This study aimed to evaluate the association of mean heart rate and heart rate variability (HRV) with the clinical outcomes after MT therapy.
methodsAcute ischemic stroke patients undergoing MT therapy were prospectively recruited from March 2020 to November 2022. Their heart rate was collected every hour for the initial 72 h after MT procedure, and the variability of heart rate was measured by standard deviation (SD) and coefficient of variation (CV). All-cause mortality and worsening of functional outcome (change in modified Rankin Scale (mRS) score) at 3-month were captured. Binary logistic regression was used to evaluate the association between heart rate indicators and all-cause mortality. Ordinal logistic regression was used to evaluate the association between heart rate indicators and worsening of functional outcome.
resultsAmong 191 MT-treated patients, 51(26.7%) patients died at 3-month after stroke. Increased mean heart rate per 10-bpm, heart rate SD and CV per 5-unit were all associated with the increased risk of mortality (adjusted hazard ratio [aHR] with 95% CI: 1.29 [1.09-1.51], 1.19 [1.07-1.32], 1.14 [1.03-1.27]; respectively). Patients in the highest tertile of heart rate SD had an increased risk of mortality (4.62, 1.70-12.52). After using mRS as a continuous variable, we found increased mean heart rate per 10-bpm, heart rate SD and CV per 5-unit were associated with the worsening of functional outcome (adjusted odds ratio [aOR] with 95% CI: 1.35 [1.11-1.64], 1.27 [1.05-1.53], 1.19 [1.02-1.40]; respectively). A linear relationship was observed between mean heart rate or heart rate SD and mortality; while all of the heart rate measures in this study showed a linear relationship with the worsening of functional outcome.
conclusionsHigher mean heart rate and HRV were associated with the increased risk of 3-month all-cause mortality and worse functional outcome after MT therapy for AIS patients.
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