ArticleBMC public health2024
The relationship between oxidative balance scores and chronic diarrhea and constipation: a population-based study.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Review
- Evaluation of a Novel Compound Probiotic Paste Containing Canine-Derived Vitamin B12-Producing Limosilactobacillus Reuteri.Current microbiology · 2026Article
- Lactobacillus delbrueckii Alleviate Oxidative Stress and Intestinal Injuries by Activating TLR2 and TLR4 Expressions in IPEC-J2 Cells.Probiotics and antimicrobial proteins · 2025Article
- The Particle Size of Wheat Bran Dietary Fiber Influences Its Improvement Effects on Constipation.Foods (Basel, Switzerland) · 2025Article
- Oxidative balance score is associated with increased risk of sarcopenia and sarcopenic obesity in non-elderly adults: results from NHANES 2011-2018.Nutrition & metabolism · 2025Article
- Association of the body roundness index with chronic diarrhea and chronic constipation: findings based on the National Health and Nutrition Examination Survey 2005-2010 data.Lipids in health and disease · 2025Article
- The association between oxidative balance score with constipation and diarrhea in US adults: a cross-sectional analysis of NHANES 2007-2010.BMC gastroenterology · 2025Article
- Association between oxidative balance score and gallstone in US adults: a cross-sectional study.Frontiers in aging · 2025Article
- Independent role of two novel abdominal fat indicators in chronic diarrhoea.Frontiers in medicine · 2025Article
- Life's Simple 7 and its impact on chronic bowel disorders: a study on constipation and diarrhea in the U.S. adult population.Frontiers in medicine · 2025Article
- Article
- Protective role of short-chain fatty acids on intestinal oxidative stress induced by TNF-α.Cell stress & chaperones · 2024Article
- The negative linear relationship between oxidative balance scores and constipation: a cross-sectional study from NHANES 2005-2010.Frontiers in medicine · 2024Article
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7 authors.
Funding
Abstract
backgroundOxidative stress is closely related to gut health. Exposures to oxidative stress in one's diet and lifestyle can be evaluated by the oxidative balance score (OBS). However, the relationship between OBS and intestinal habits is unknown. This study aimed to investigate the relationships between OBS and intestinal habits (chronic diarrhea and chronic constipation) and the underlying mechanisms involved.
methodsUsing data from the National Health and Nutrition Examination Survey (NHANES) database from 2005 to 2010, we included a total of 8065 participants. Twenty dietary and lifestyle factors were selected for the OBS calculates. Chronic constipation and chronic diarrhea were defined using the Bristol stool form scale (BSFS) types 1 and 2 and the BSFS 6 and 7, respectively. Multivariate logistic regression, subgroup analysis, and restricted cubic splines (RCS) analysis were used to evaluate the relationship between OBS and defecation habits. Finally, we used mediation analysis to explore the indirect effects of oxidative stress and inflammatory markers on these associations.
resultsAfter adjusting for all the covariates, multivariate logistic regression analysis revealed that OBS was negatively correlated with diarrhea (OR = 0.57; 95%CI = 0.39-0.83; P = 0.008)and positively correlated with constipation (OR = 1.75; 95%CI = 1.19-2.25; P = 0.008). The RCS showed a nonlinear relationship between OBS and diarrhea (P for nonlinearity = 0.02) and a linear relationship between OBS and constipation (P for nonlinearity = 0.19). Mediation analysis showed that the C-reactive protein (CRP) concentration and white blood cell (WBC) count mediated the correlation between OBS and diarrhea by 6.28% and 6.53%, respectively (P < 0.05).
conclusionsOBS is closely related to changes in patients' defecation habits. Oxidative stress and inflammation may play a role in the relationship between the two. This result emphasizes the importance of the public adjusting their lifestyle and dietary habits according to their own situation. However, further prospective studies are needed to analyze the relationship between oxidative stress and changes in defecation habits.
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