Evidence map›Paper›PMID 38773369›Full record

ArticleBMC genomics2024

Apelin-13 modulates the endometrial transcriptome of the domestic pig during implantation.

Kamil Dobrzyn, Marta Kiezun, Grzegorz Kopij, Barbara Zarzecka, Marlena Gudelska, Katarzyna Kisielewska, Ewa Zaobidna, Karol G Makowczenko, Cecilia Dall'Aglio, Tadeusz Kamiński and 1 more

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In one paragraph

Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kamil Dobrzyn *Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, Olsztyn, 10-719, Poland. kamil.dobrzyn@uwm.edu.pl.
Marta Kiezun *Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, Olsztyn, 10-719, Poland.
Grzegorz KopijFaculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, Olsztyn, 10-719, Poland.
Barbara ZarzeckaFaculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, Olsztyn, 10-719, Poland.
Marlena GudelskaFaculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Aleja Warszawska 30, Olsztyn, 10-082, Poland.
Katarzyna KisielewskaFaculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Aleja Warszawska 30, Olsztyn, 10-082, Poland.
Ewa ZaobidnaFaculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, Olsztyn, 10-719, Poland.
Karol G MakowczenkoInstitute of Animal Reproduction and Food Research of Polish Academy of Sciences, Department of Reproductive Immunology and Pathology, Tuwima 10, Olsztyn, 10-748, Poland.
Cecilia Dall'AglioDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, Perugia, 06126, Italy.
Tadeusz KamińskiFaculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, Olsztyn, 10-719, Poland.
Nina SmolińskaFaculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, Olsztyn, 10-719, Poland.

Funding

Narodowe Centrum Nauki 2018/31/N/NZ9/00544Narodowe Centrum Nauki 2019/03/X/NZ9/00213
6 · The paper itself

Abstract

backgroundThe peri-implantation period is a critical time during pregnancy that mostly defines the overall litter size. Most authors agree that the highest percentage of embryo mortality occurs during this time. Despite the brevity of the peri-implantation period, it is the most dynamic part of pregnancy in which the sequential and uninterrupted course of several processes is essential to the animal's reproductive success. Also then, the maternal uterine tissues undergo an intensive remodelling process, and their energy demand dramatically increases. It is believed that apelin, a member of the adipokine family, is involved in the control of female reproductive functions in response to the current metabolic state. The verified herein hypothesis assumed the modulatory effect of apelin on the endometrial tissue transcriptome on days 15 to 16 of gestation (beginning of implantation).

resultsThe analysis of data obtained during RNA-seq (Illumina HiSeq2500) of endometrial slices treated and untreated with apelin (n = 4 per group) revealed changes in the expression of 68 genes (39 up-regulated and 29 down-regulated in the presence of apelin), assigned to 240 gene ontology terms. We also revealed changes in the frequency of alternative splicing events (397 cases), as well as single nucleotide variants (1,818 cases) in the presence of the adipokine. The identified genes were associated, among others, with the composition of the extracellular matrix, apoptosis, and angiogenesis.

conclusionsThe obtained results indicate a potential role of apelin in the regulation of uterine tissue remodelling during the peri-implantation period.

Indexed as

Embryo ImplantationEndometriumTranscriptomeAlternative SplicingAnimalsApelinFemaleGene Expression ProfilingIntercellular Signaling Peptides and ProteinsPregnancySwineApelinapelin-13 peptideIntercellular Signaling Peptides and ProteinsAdipokineAlternative splicingAngiogenesisApelinApoptosisDifferentially expressed genesEndometriumRNA-SeqTranscriptome

Identifiers

PMID38773369
PMCPMC11106924

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.