Evidence map›Paper›PMID 38773230›Full record

ArticleThe Journal of antibiotics2024

The new seriniquinone glycoside by biological transformation using the deep sea-derived bacterium Bacillus licheniformis KDM612.

Ryota Okamura, Katsuki Kikuchi, Akito Taniguchi, Kenichiro Nagai, Reiko Seki, Satoshi Ohte, Taichi Ohshiro, Masashi Ando, Teruyoshi Tanaka, Takashi Fukuda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of antibiotics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ryota OkamuraDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
Katsuki KikuchiDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
Akito TaniguchiDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
Kenichiro NagaiMicrobial Chemistry and Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Reiko SekiMicrobial Chemistry and Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Satoshi OhteMicrobial Chemistry and Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.ORCID 0000-0002-5153-2176
Taichi OhshiroMicrobial Chemistry and Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Masashi AndoDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
Teruyoshi TanakaDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
Takashi FukudaDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan. fukudata@nara.kindai.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seriniquinone was isolated as a melanoma-selective anti-cancer agent from a culture broth of the marine-derived bacterium Serinicoccus marinus CNJ927 in 2014. It targets the unique small protein, dermcidin, which affects the drug resistance of cancer cells. Due to its significant activity against cancer cells, particularly melanoma, and its unique target, seriniquinone has been developed as a new pharmacophore. However, it has the disadvantage of poor solubility in drug discovery research, which needs to be resolved. A new seriniquinone glycoside (1) was synthesized by the biological transformation of seriniquinone using the deep sea-derived bacterium Bacillus licheniformis KDM612. Compound 1 exhibited selective anti-cancer activity against melanoma, similar to seriniquinone, and was 50-fold more soluble in DMSO than seriniquinone.

Indexed as

Antineoplastic AgentsBacillus licheniformisGlycosidesBiotransformationCell Line, TumorHumansQuinonesSolubilityAntineoplastic AgentsGlycosidesQuinonesseriniquinone

Identifiers

PMID38773230
PMCPMC11284089

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.