Evidence map›Paper›PMID 38773113›Full record

ArticleNature communications2024

Post-resolution macrophages shape long-term tissue immunity and integrity in a mouse model of pneumococcal pneumonia.

Karen T Feehan, Hannah E Bridgewater, Jan Stenkiewicz-Witeska, Roel P H De Maeyer, John Ferguson, Matthias Mack, Jeremy Brown, Giuseppe Ercoli, Connar M Mawer, Arne N Akbar and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Prophylactic immune priming with heat-killedFrontiers in immunology · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Karen T FeehanDepartment for Experimental and Translational Medicine, Division of Medicine, 5 University Street, University College London, London, WC1E 6JJ, UK.ORCID http://orcid.org/0000-0001-9279-8053
Hannah E BridgewaterDepartment for Experimental and Translational Medicine, Division of Medicine, 5 University Street, University College London, London, WC1E 6JJ, UK.ORCID http://orcid.org/0000-0003-1769-9025
Jan Stenkiewicz-WiteskaDepartment for Experimental and Translational Medicine, Division of Medicine, 5 University Street, University College London, London, WC1E 6JJ, UK.
Roel P H De MaeyerNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Windmill Road, University of Oxford, OX3 7LD, Oxford, UK.ORCID http://orcid.org/0000-0003-4041-0867
John FergusonTranslational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Matthias MackUniversitätsklinikum Regensburg, Innere Medizin II/Nephrologie-Transplantation, Regensburg, Germany.ORCID http://orcid.org/0000-0002-3157-7262
Jeremy BrownUCL Respiratory, Division of Medicine, 5 University Street, University College London, London, WC1E 6JJ, UK.ORCID http://orcid.org/0000-0002-5650-5361
Giuseppe ErcoliUCL Respiratory, Division of Medicine, 5 University Street, University College London, London, WC1E 6JJ, UK.ORCID http://orcid.org/0000-0001-7326-1680
Connar M MawerUCL Respiratory, Division of Medicine, 5 University Street, University College London, London, WC1E 6JJ, UK.ORCID http://orcid.org/0009-0003-4997-5028
Arne N AkbarDepartment for Experimental and Translational Medicine, Division of Medicine, 5 University Street, University College London, London, WC1E 6JJ, UK.ORCID http://orcid.org/0000-0002-3763-9380
James R W GlanvilleDepartment for Experimental and Translational Medicine, Division of Medicine, 5 University Street, University College London, London, WC1E 6JJ, UK.
Parinaaz JalaliDepartment for Experimental and Translational Medicine, Division of Medicine, 5 University Street, University College London, London, WC1E 6JJ, UK.
Olivia V BrackenDepartment for Experimental and Translational Medicine, Division of Medicine, 5 University Street, University College London, London, WC1E 6JJ, UK.
Anna NicolaouLaboratory for Lipidomics and Lipid Biology, Division of Pharmacy and Optometry, School of Health Sciences, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK.ORCID http://orcid.org/0000-0002-1314-413X
Alexandra C KendallLaboratory for Lipidomics and Lipid Biology, Division of Pharmacy and Optometry, School of Health Sciences, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK.ORCID http://orcid.org/0000-0003-4419-0013
Michelle A SugimotoDepartment for Experimental and Translational Medicine, Division of Medicine, 5 University Street, University College London, London, WC1E 6JJ, UK.
Derek W GilroyDepartment for Experimental and Translational Medicine, Division of Medicine, 5 University Street, University College London, London, WC1E 6JJ, UK. d.gilroy@ucl.ac.uk.ORCID http://orcid.org/0000-0003-3476-0844

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resolving inflammation is thought to return the affected tissue back to homoeostasis but recent evidence supports a non-linear model of resolution involving a phase of prolonged immune activity. Here we show that within days following resolution of Streptococcus pneumoniae-triggered lung inflammation, there is an influx of antigen specific lymphocytes with a memory and tissue-resident phenotype as well as macrophages bearing alveolar or interstitial phenotype. The transcriptome of these macrophages shows enrichment of genes associated with prostaglandin biosynthesis and genes that drive T cell chemotaxis and differentiation. Therapeutic depletion of post-resolution macrophages, inhibition of prostaglandin E2 (PGE

Indexed as

MacrophagesPneumonia, PneumococcalStreptococcus pneumoniaeAnimalsDinoprostoneFibrosisInflammationLungLymphocytesMacrophages, AlveolarMaleMiceMice, Inbred C57BLPhagocytesProstaglandinsQuinolinesDinoprostoneN-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamideProstaglandinsQuinolinesSulfonamides

Identifiers

PMID38773113
PMCPMC11109210

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.