ArticleNature communications2024
Self-organization of modular activity in immature cortical networks.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Interneuron and glial mechanisms underlying V1 orientation map dynamics.IBRO neuroscience reports · 2026Article
- Millimeter-scale selective amplification in the developing visual cortex.bioRxiv : the preprint server for biology · 2026Article
- Principles of cortical interactions in modular recurrent networks.bioRxiv : the preprint server for biology · 2026Article
- Iso-orientation bias of layer 2/3 connections unifies spontaneous, visually and optogenetically driven V1 dynamics.Nature communications · 2026Article
- Article
- Connectivity, Computation, and Plasticity of the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Stereotyped Spatiotemporal Dynamics of Spontaneous Activity in Visual Cortex Prior to Eye Opening.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Developmental maturation of millimeter-scale functional networks across brain areas.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Article
- Optogenetic Stimulation Recruits Cortical Neurons in a Morphology-Dependent Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Developmental maturation of millimeter-scale functional networks across brain areas.bioRxiv : the preprint server for biology · 2024Article
- Self-organization of modular activity in immature cortical networks.Nature communications · 2024Article
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3 authors.
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Abstract
During development, cortical activity is organized into distributed modular patterns that are a precursor of the mature columnar functional architecture. Theoretically, such structured neural activity can emerge dynamically from local synaptic interactions through a recurrent network with effective local excitation with lateral inhibition (LE/LI) connectivity. Utilizing simultaneous widefield calcium imaging and optogenetics in juvenile ferret cortex prior to eye opening, we directly test several critical predictions of an LE/LI mechanism. We show that cortical networks transform uniform stimulations into diverse modular patterns exhibiting a characteristic spatial wavelength. Moreover, patterned optogenetic stimulation matching this wavelength selectively biases evoked activity patterns, while stimulation with varying wavelengths transforms activity towards this characteristic wavelength, revealing a dynamic compromise between input drive and the network's intrinsic tendency to organize activity. Furthermore, the structure of early spontaneous cortical activity - which is reflected in the developing representations of visual orientation - strongly overlaps that of uniform opto-evoked activity, suggesting a common underlying mechanism as a basis for the formation of orderly columnar maps underlying sensory representations in the brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.