ArticleNature communications2024
Deep learning of left atrial structure and function provides link to atrial fibrillation risk.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Circulating Proteomics and Risk of Atrial Fibrillation: A Systematic Review of Cohort Studies.Journal of cellular and molecular medicine · 2025Pooled it
- A meta-learning method with reduced data requirements for training and updating deep learning models on wearable devices.Communications medicine · 2026Article
- Three-Dimensional Left Atrial Geometry in Atrial Fibrillation: Imaging Biomarkers, Substrate Phenotyping, and Ablation Outcome Prediction.Diagnostics (Basel, Switzerland) · 2026Review
- Left atrial strain on 2D-STE in pediatric dilated cardiomyopathy.Echo research and practice · 2026Article
- Genetic analysis of imaging-derived phenotypes.Nature reviews. Genetics · 2026Review
- Associations of the triglyceride-glucose index and its obesity-related derivatives with cardiac structure, function, and incident atrial fibrillation: a prospective cohort study using cardiac magnetic resonance.Cardiovascular diabetology · 2026Article
- Vericiguat Alleviates Atrial Electrical and Structural Remodeling in Rats with Atrial Fibrillation.Anatolian journal of cardiology · 2026Article
- Precision cardiovascular medicine with big data and AI.NPJ digital medicine · 2026Review
- Modifiable Lifestyle Factors, Left Atrial Indices, and Atrial Fibrillation.Journal of the American Heart Association · 2026Article
- Right and Left Atrial Dysfunction as Independent Cardiovascular Risk Factors: A UK Biobank Study.Circulation. Arrhythmia and electrophysiology · 2026Article
- Correlation of glycemic variability with the risk of atrial fibrillation and in-hospital mortality in patients diagnosed with obstructive sleep apnea: a retrospective study based on the Medical Information Mart for Intensive Care database.Journal of thoracic disease · 2026Article
- Atrial cardiomyopathy: markers and outcomes.European heart journal · 2026Article
- mCardiacDx: Radar-Driven Contactless Monitoring and Diagnosis of Atrial Fibrillation.IEEE journal of translational engineering in health and medicine · 2026Article
- Causality of atrial fibrillation and left atrial traits: Genetic and epigenetic perspectives.Heart rhythm O2 · 2026Article
- Artificial Intelligence Tools in Myocardial Infarction Prognosis: Evaluating the Performance of Machine Learning and Deep Learning Models.Current cardiology reviews · 2026Review
- Development of a predictive model for in-hospital new-onset atrial fibrillation in older adults with hypertension and acute myocardial infarction, enhanced by SHAP interpretability: a retrospective cohort study.Frontiers in medicine · 2026Article
- A Representation Fusion Framework for Decoupling Diagnostic Information in Multimodal Learning.NPJ digital medicine · 2025Article
- SGLT2 inhibitors and left atrial function in heart failure with reduced or mildly reduced ejection fraction.BMC cardiovascular disorders · 2025Observational
- Atrial cardiomyopathy: From healthy atria to atrial failure. A clinical consensus statement of the Heart Failure Association of the ESC.European journal of heart failure · 2025Article
- Left Atrial Mechanics and Remodeling in Paroxysmal Atrial Fibrillation: Introducing the EASE Score for Pre-Ablation Risk Prediction.Medical sciences (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
Increased left atrial volume and decreased left atrial function have long been associated with atrial fibrillation. The availability of large-scale cardiac magnetic resonance imaging data paired with genetic data provides a unique opportunity to assess the genetic contributions to left atrial structure and function, and understand their relationship with risk for atrial fibrillation. Here, we use deep learning and surface reconstruction models to measure left atrial minimum volume, maximum volume, stroke volume, and emptying fraction in 40,558 UK Biobank participants. In a genome-wide association study of 35,049 participants without pre-existing cardiovascular disease, we identify 20 common genetic loci associated with left atrial structure and function. We find that polygenic contributions to increased left atrial volume are associated with atrial fibrillation and its downstream consequences, including stroke. Through Mendelian randomization, we find evidence supporting a causal role for left atrial enlargement and dysfunction on atrial fibrillation risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.