Evidence map›Paper›PMID 38772979›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Clinical features of COVID-19-related encephalitis: comparison with the features of herpes virus encephalitis and autoimmune encephalitis.

Yue Cui, Zhongyun Chen, Yu Kong, Yingtao Wang, Yihao Wang, Jing Zhang, Lin Wang, Jiatang Zhang, Wei Sun, Liyong Wu

Abstract readComparative Study
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Anti-LGI1 encephalitis in a COVID-19 patient with positive SARS-CoV-2 in CSF.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yue CuiDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Zhongyun ChenDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yu KongDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yingtao WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yihao WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jing ZhangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Lin WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jiatang ZhangDepartment of Neurology, The First Medical Centre, Chinese PLA General Hospital, Beijing, China.
Wei Sun *Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. bmusunnyw@163.com.
Liyong Wu *Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. wmywly@hotmail.com.ORCID http://orcid.org/0000-0002-0684-6248

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIdentifying coronavirus disease 2019 (COVID-19)-related encephalitis without clear etiological evidence is clinically challenging. The distinctions between this condition and other prevalent encephalitis types remain unknown. Therefore, we aimed to explore the similarities and differences in the clinical characteristics of COVID-19-related encephalitis and other encephalitis types.

methodsAdult patients with encephalitis admitted to the neurology department at Xuanwu Hospital were enrolled and categorized into the following six groups based on the results of metagenomic next-generation sequencing and autoimmune antibody detection in cerebrospinal fluid (CSF): COVID-19-related encephalitis (n = 36), herpes simplex virus type 1 encephalitis (HSV-1 encephalitis; n = 28), human herpesvirus 3 encephalitis (HHV-3 encephalitis; n = 10), NMDAR-antibody encephalitis (n = 18), LGI1-antibody encephalitis (n = 12), and GABAB-antibody encephalitis (n = 8).

resultsThe predominant characteristics of COVID-19-related encephalitis include a low incidence of seizures (38.9%), cognitive defects (30.6%), and meningeal irritation signs (8.3%). Compared with HSV-1 and HHV-3 encephalitis, COVID-19-related encephalitis exhibited lower white blood cell count (2.5 count/mm DISCUSSION: COVID-19-related encephalitis and herpes virus or autoimmune encephalitis differ clinically. Symptoms and auxiliary examinations can be used as distinguishing tools.

Indexed as

COVID-19EncephalitisEncephalitis, Herpes SimplexHashimoto DiseaseAdultAgedAnti-N-Methyl-D-Aspartate Receptor EncephalitisAutoantibodiesEncephalitis, ViralFemaleHumansMaleMiddle AgedSARS-CoV-2AutoantibodiesCOVID-19-related encephalitisIntracranial inflammationSARS-CoV-2 infection

Identifiers

PMID38772979
PMCPMC11254958

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.