ReviewGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2024
SMARCA4-deficient undifferentiated gastric carcinoma: a case series and literature review.
Review in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Small intestinal SMARCA4-deficient undifferentiated carcinoma with intussusception: A case report.Oncology letters · 2026Article
- Clinico-pathologic characteristics of sub-epithelial tumor (SET) like gastric cancers.Scientific reports · 2026Article
- Disitamab vedotin combined with anti-PD-1 antibody in a patient with SMARCA4-mutated gastric cancer: a case report.Frontiers in oncology · 2026Article
- A case report of SMARCA4-deficient undifferentiated gastric carcinoma diagnosed by endoscopic ultrasound-guided fine needle aspiration.Frontiers in oncology · 2026Article
- Stable disease after multimodal treatment of SMARCA4-deficient undifferentiated tumor concurrently involving the stomach and mediastinum: a case report.Frontiers in oncology · 2026Article
- Case Report: A successfully managed case of SMARCA4-deficient undifferentiated gastric carcinoma.Frontiers in oncology · 2026Article
- A case report of thoracic SMARCA4-deficient undifferentiated tumor associated with brain metastases.Frontiers in oncology · 2026Article
- SMARCA4-Deficient Undifferentiated Carcinoma: A Report of 2 Cases.The American journal of case reports · 2025Article
- Gastric SMARCA4-deficient undifferentiated tumors: clinicopathological analysis of two cases in a single center.Diagnostic pathology · 2025Article
- Case Report: Recognition and management of SMARCA4-deficient renal cell carcinoma.Frontiers in oncology · 2025Article
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Authors and funding
4 authors.
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Abstract
Undifferentiated gastric carcinoma, characterized by anaplastic cells lacking distinct features of cytological or architectural differentiation, poses diagnostic and therapeutic challenges. Recent studies have suggested an association between this carcinoma and deficiencies in the SWI/SNF complex, particularly mutations in subunits such as SMARCA4. We herein report six cases of SMARCA4-deficient undifferentiated gastric carcinoma with molecular findings, highlighting the rarity and diagnostic pitfalls of this malignancy. Predominantly occurring in males over 50 years, these cases presented with nonspecific symptoms and were often diagnosed at an advanced stage. Histologically, the tumors exhibited a sheet-like growth pattern, reduced or absent epithelial markers, and loss of BRG-1 expression, with molecular analysis confirming SMARCA4 gene mutations. The response to conventional chemotherapy was poor, underscoring the importance of complete surgical resection and the development of alternative treatment modalities.
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