Evidence map›Paper›PMID 38772965›Full record

SynthesisInternational urology and nephrology2024

A systematic review of kidney transplantation outcomes in patients with end-stage renal disease due to childhood lower urinary tract malformations.

Hakan Bahadir Haberal, Muhammet Irfan Donmez, Alberto Piana, Alessio Pecoraro, Thomas Prudhomme, Beatriz Bañuelos Marco, Alicia López-Abad, Riccardo Campi, Romain Boissier, Alberto Breda and 2 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International urology and nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hakan Bahadir Haberal *Department of Urology, Ankara Ataturk Sanatorium Training and Research Hospital, Ministry of Health, University of Health Sciences, 06290, Ankara, Turkey. bahadirhaberal@gmail.com.
Muhammet Irfan Donmez *Department of Urology, Division of Pediatric Urology, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey.
Alberto PianaDepartment of Urology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Turin, Italy.
Alessio PecoraroUnit of Urological Robotic Surgery and Renal Transplantation, Careggi Hospital, University of Florence, Florence, Italy.
Thomas PrudhommeDepartment of Urology and Kidney Transplantation, Rangueil University Hospital, Toulouse, France.
Beatriz Bañuelos MarcoDepartment of Urology, Renal Transplant Division, University Hospital Clínico San Carlos, Madrid, Spain.
Alicia López-AbadDepartment of Urology, Virgen de La Arrixaca University Hospital, Murcia, Spain.
Riccardo CampiUnit of Urological Robotic Surgery and Renal Transplantation, Careggi Hospital, University of Florence, Florence, Italy.
Romain BoissierDepartment of Urology and Renal Transplantation, La Conception University Hospital, Marseille, France.
Alberto BredaUro-Oncology and Kidney Transplant Unit, Department of Urology at "Fundació Puigvert" Hospital, Autonoma University of Barcelona, Barcelona, Spain.
Angelo TerritoUro-Oncology and Kidney Transplant Unit, Department of Urology at "Fundació Puigvert" Hospital, Autonoma University of Barcelona, Barcelona, Spain.
EAU Young Academic Urologists (YAU) Kidney Transplantation Working Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePatients with lower urinary tract malformations (LUTM) were suspended from kidney transplantation (KT) programs in the past due to various concerns. Consequently, only a limited number of studies have explored this topic at hand. In this study, our objective was to perform a systematic review (SR) to evaluate the current evidence regarding KT outcomes as well as patient survival (PS), postoperative complications and urinary tract infections (UTI) in individuals with childhood LUTM.

methodsThe search encompassed databases of Web of Science, Medline (via PubMed), and Embase (via Scopus) to identify all studies reporting outcomes on KT for patients with LUTM. The research included articles published in English from January 1995 till September 2023.

resultsOf the 2634 yielded articles, 15 met the inclusion criteria, enrolling a total of 284,866 KT patients. There was significantly better 5-year graft survival (GS) in recipients with LUTM compared to the control group (RR, 1.04; 95% CI 1.02-1.06); while GS at 1-year and 10-year, and PS at 1-year, 5-year and 10-year were similar between groups. On the other hand, the postoperative UTI rate was significantly higher in the LUTM group (RR: 4.46; 95% CI 1.89-10.51). However, data on serum creatinine and estimated glomerular filtration rate on follow-up were insufficient.

conclusionGS and PS rates appear to be similar in patients with childhood LUTM and those with normal lower urinary tract functions. Despite a higher postoperative UTI rate within this patient group, it appears that this has no effect on GS rates.

Indexed as

Kidney Failure, ChronicKidney TransplantationPostoperative ComplicationsUrinary TractAdolescentChildGraft SurvivalHumansTreatment OutcomeUrinary Tract InfectionsYoung AdultCongenital abnormalitiesEnd-stage renal diseaseGraft survivalKidney transplantationUrinary tract

Identifiers

PMID38772965

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.