Evidence map›Paper›PMID 38772951›Full record

ArticleParasitology research2024

Essential oil of oregano (Origanum vulgare L.) reduces infection and proliferation of Toxoplasma gondii in BeWo cells with induction of autophagy and death of tachyzoites through a mechanism similar to necrosis.

Angélica Paulina Nunes, Yasmin Munhoz Dos Santos, Raquel Arruda da Silva Sanfelice, Virgínia Marcia Concato-Lopes, Taylon Felipe Silva, Fernanda Tomiotto-Pellissier, Danielle Lazarin-Bidoia, Rayanne Regina Beltrame Machado, Luiz Daniel de Barros, João Luis Garcia and 6 more

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In one paragraph

Article in Parasitology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Angélica Paulina NunesDepartment of Immunology, Parasitology and General Pathology - Laboratory of Experimental Immunoparasitology, State University of Londrina, Londrina, Paraná, Brazil.
Yasmin Munhoz Dos SantosDepartment of Immunology, Parasitology and General Pathology - Laboratory of Experimental Immunoparasitology, State University of Londrina, Londrina, Paraná, Brazil.
Raquel Arruda da Silva SanfeliceDepartment of Immunology, Parasitology and General Pathology - Laboratory of Experimental Immunoparasitology, State University of Londrina, Londrina, Paraná, Brazil.
Virgínia Marcia Concato-LopesDepartment of Immunology, Parasitology and General Pathology - Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina, Paraná, Brazil.
Taylon Felipe SilvaDepartment of Immunology, Parasitology and General Pathology - Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina, Paraná, Brazil.
Fernanda Tomiotto-PellissierDepartment of Immunology, Parasitology and General Pathology - Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina, Paraná, Brazil.
Danielle Lazarin-BidoiaDepartment of Immunology, Parasitology and General Pathology - Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina, Paraná, Brazil.
Rayanne Regina Beltrame MachadoDepartment of Immunology, Parasitology and General Pathology - Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina, Paraná, Brazil.
Luiz Daniel de BarrosDepartment of Veterinary Medicine - Laboratory of Animal Protozoology, State University of Londrina, Londrina, Paraná, Brazil.
João Luis GarciaDepartment of Veterinary Medicine - Laboratory of Animal Protozoology, State University of Londrina, Londrina, Paraná, Brazil.
Ivete Conchon-CostaDepartment of Immunology, Parasitology and General Pathology - Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina, Paraná, Brazil.
Wander Rogério PavanelliDepartment of Immunology, Parasitology and General Pathology - Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina, Paraná, Brazil.
Renata Katsuko Takayama KobayashiDepartment of Microbiology - Laboratory of Basic and Applied Bacteriology, State University of Londrina, Londrina, Paraná, Brazil.
Bellisa de Freitas BarbosaDepartment of Cell Biology, Histology and Embryology - Laboratory of Reproduction Immunophysiology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
Eloisa Amália Vieira FerroDepartment of Cell Biology, Histology and Embryology - Laboratory of Reproduction Immunophysiology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
Idessania Nazareth CostaDepartment of Immunology, Parasitology and General Pathology - Laboratory of Experimental Immunoparasitology, State University of Londrina, Londrina, Paraná, Brazil. idessania@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toxoplasmosis poses a global health threat, ranging from asymptomatic cases to severe, potentially fatal manifestations, especially in immunocompromised individuals and congenital transmission. Prior research suggests that oregano essential oil (OEO) exhibits diverse biological effects, including antiparasitic activity against Toxoplasma gondii. Given concerns about current treatments, exploring new compounds is important. This study was to assess the toxicity of OEO on BeWo cells and T. gondii tachyzoites, as well as to evaluate its effectiveness in in vitro infection models and determine its direct action on free tachyzoites. OEO toxicity on BeWo cells and T. gondii tachyzoites was assessed by MTT and trypan blue methods, determining cytotoxic concentration (CC

Indexed as

AutophagyOils, VolatileOriganumReactive Oxygen SpeciesToxoplasmaAntiprotozoal AgentsApoptosisCell LineCell SurvivalHumansInhibitory Concentration 50Membrane Potential, MitochondrialNecrosisAntiprotozoal AgentsOils, VolatileReactive Oxygen SpeciesBeWo cellCongenitalOriganum vulgareRH strainToxoplasmosis

Identifiers

PMID38772951

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.