Trial reportRespiratory care2024
Effect of Reintubation Within 48 Hours on Mortality in Critically Ill Patients After Planned Extubation.
Trial report in Respiratory care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- A Reproducible Post-Valve-Replacement EHR Cohort for Comparative AI Studies.Diagnostics (Basel, Switzerland) · 2026Article
- Long-term impact of a quality improvement program on unplanned extubation and clinical outcomes in adult intensive care units: a 24-year single-center observational study.Frontiers in medicine · 2026Article
- The diaphragm-intercostal index for predicting weaning failure in mechanically ventilated patients: a prospective cohort study.Frontiers in medicine · 2026Article
- "One-way" clinical extubation: an alternative to tracheostomy or palliative extubation in patients receiving inappropriate mechanical ventilation?Critical care science · 2026Article
- Article
- Circulating and Respiratory Biomarkers in Sepsis-Induced ARDS: Diagnostic and Prognostic Insights - A Narrative Review.Journal of inflammation research · 2026Review
- Construction and validation of a machine learning-based prediction model for 48-hour reintubation risk in mechanically ventilated patients.Frontiers in medicine · 2026Article
- Incidence and predictors of extubation failure among adult intensive care unit patients in Northwest Amhara comprehensive specialized hospitals.Scientific reports · 2025Article
- The ability of diaphragmatic excursion after extubation to predict the need for resumption of ventilatory support in critically ill surgical patients.Journal of anesthesia · 2025Observational
- Clinical predictors of extubation failure in postoperative critically ill patients: a post-hoc analysis of a multicenter prospective observational study.BMC anesthesiology · 2025Observational
- Risk factors for failed extubation within 7 days in elderly critically ill patients based on respiratory mechanics and clinical indicators: a retrospective cohort study.Frontiers in medicine · 2025Article
- Prolonged weaning from mechanical ventilation: who, what, when and how?Breathe (Sheffield, England) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRe-intubation is necessary in 2% to 30% of cases of patients receiving a planned extubation. This procedure is associated with prolonged mechanical ventilation, a greater need for tracheostomy, a higher incidence of ventilator-associated pneumonia, and higher mortality. The aim of this study was to evaluate the effect of re-intubation within 48 h on mortality after planned extubation by using a randomized controlled trial database.
methodsSecondary analysis of a multi-center randomized trial, which evaluated the effect of reconnection to mechanical ventilation for 1 h after a successful spontaneous breathing trial, followed by extubation. The study included adult subjects who received invasive mechanical ventilation for > 12 h. The subjects were divided into an extubation failure group and an extubation success group. The outcome was in-hospital mortality. Two multivariate logistic regression models were constructed to identify independent factors associated with mortality.
resultsAmong the 336 subjects studied, extubation failed in 52 (15.4%) and they were re-intubated within 48 h. Most re-intubations occurred between 12 and 24 h after planned extubation (median [interquartile range] 16 [6-36] h). Mortality of the extubation failure group was higher both in the ICU (32.6% vs 6.6%; odds ratio [OR] 6.77, 95% CI 3.22-14.24;
conclusionsRe-intubation within 48 h after planned extubation was associated with mortality in subjects who were critically ill.
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