Evidence map›Paper›PMID 38771873›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood.

Gary R Turner, Patrick Hewan, Alfie Wearn, Roel van Dooren, Lindsay Wyatt, Ilana R Leppert, Giulia Baracchini, Colleen Hughes, Kayla M Williams, Elisabeth Sylvain and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The PREVENT-AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Gary R Turner *Department of Psychology, York University, Toronto, ON M3J 1P3, Canada.
Patrick HewanDepartment of Psychology, York University, Toronto, ON M3J 1P3, Canada.
Alfie WearnDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Roel van DoorenInstitutes of Psychology & Brain and Cognition, Leiden University, Leiden 2300 RC, The Netherlands.
Lindsay WyattDepartment of Psychology, York University, Toronto, ON M3J 1P3, Canada.
Ilana R LeppertMcConnell Brain Imaging Centre, McGill University, Montreal, QC H2A 2B4, Canada.
Giulia BaracchiniDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.ORCID 0000-0001-9198-2780
Colleen HughesDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Kayla M WilliamsDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Elisabeth SylvainDouglas Mental Health University Institute, Verdun, QC H4H 1R3, Canada.
Jennifer Tremblay-MercierDouglas Mental Health University Institute, Verdun, QC H4H 1R3, Canada.
Judes PoirierDouglas Mental Health University Institute, Verdun, QC H4H 1R3, Canada.
Sylvia VilleneuveMcConnell Brain Imaging Centre, McGill University, Montreal, QC H2A 2B4, Canada.ORCID 0000-0003-2338-0467
Christine TardifDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
R Nathan Spreng *Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.ORCID 0000-0003-1530-8916
PREVENT-AD Research Group

Funding

Investigating the impact of loneliness on brain aging and pre-symptomatic Alzheimer's disease progressionR01AG068563 · NIA · MCGILL UNIVERSITY · PI BZDOK, DANILO, SPRENG, ROBERT NATHAN · 2020 to 2024
$2.3M
Alzheimer's Association (AA) AARG-22-927100Canadian Government | Canadian Institutes of Health Research (CIHR) naNIA NIH HHS R01 AG068563
6 · The paper itself

Abstract

Optimal decision-making balances exploration for new information against exploitation of known rewards, a process mediated by the locus coeruleus and its norepinephrine projections. We predicted that an exploitation-bias that emerges in older adulthood would be associated with lower microstructural integrity of the locus coeruleus. Leveraging in vivo histological methods from quantitative MRI-magnetic transfer saturation-we provide evidence that older age is associated with lower locus coeruleus integrity. Critically, we demonstrate that an exploitation bias in older adulthood, assessed with a foraging task, is sensitive and specific to lower locus coeruleus integrity. Because the locus coeruleus is uniquely vulnerable to Alzheimer's disease pathology, our findings suggest that aging, and a presymptomatic trajectory of Alzheimer's related decline, may fundamentally alter decision-making abilities in later life.

Indexed as

AgingDecision MakingLocus CoeruleusMagnetic Resonance ImagingAgedAged, 80 and overAlzheimer DiseaseFemaleHumansMaleMiddle AgedRewardagingdecision-makinghumanMRI

Identifiers

PMID38771873
PMCPMC11145298

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.