ArticlePloS one2024
Sepsis risk in diabetic patients with urinary tract infection.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Septic cardiomyopathy: a rare and life-threatening complication of small intestinal perforation: A case report.Medicine · 2026Article
- Clinical Profiles, Interventions, and Outcomes of Sepsis and Septic Shock in a Saudi Arabian Tertiary ICU: A Five-Year Retrospective Analysis.Healthcare (Basel, Switzerland) · 2026Article
- Epigenetic regulation by HDAC11-driven STAT3 activation promotes pro-inflammatory cytokine production and endothelial dysfunction upon bacterial infection in diabetes.Cell communication and signaling : CCS · 2026Article
- Development and validation of a prediction model for urinary tract infection in older patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2026Article
- Risk Factors for Urinary Tract Infection in Gynecological Malignant Tumor Inpatients: A Retrospective Study.Infection and drug resistance · 2026Article
- A Host-Clinical Integrated Prediction Model for Early Sepsis Risk in Diabetic Patients with Acute Infections: Development and Internal Validation.Journal of inflammation research · 2026Article
- Risk factors and prediction model for mortality risk in older adults septic patients.Frontiers in medicine · 2026Article
- The Development and Validation of a Nomogram for Predicting Sepsis Risk in Diabetic Patients with Urinary Tract Infection.Medicina (Kaunas, Lithuania) · 2025Observational
- Immunometabolic crossroads: infections as bidirectional modulators in diabetes and metabolic syndromes.Frontiers in endocrinology · 2025Review
- Comparison of antibiotic resistance and molecular characteristics ofFrontiers in medicine · 2025Article
- Analysis of pathogen distribution and serum procalcitonin level alterations in patients with type 2 diabetes mellitus complicated by urinary tract infections.Frontiers in endocrinology · 2025Article
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5 authors.
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Abstract
backgroundUrinary tract infections (UTI) is a prevalent condition in those with diabetes, and in severe cases, it may escalate to sepsis. Therefore, it is important to analyze the risk variables associated with sepsis in diabetes individuals with UTI.
methodsThis research was a retrospective cross-sectional analysis. From January 2011 to June 2022, a group of individuals with diabetes were identified as having UTI at a tertiary hospital situated in Southeastern China. Patient data, including information on urine culture, was collected retrospectively from a clinical record database. The participants were categorized into the sepsis and non-sepsis groups. The risk variables were derived using both uni-and multiple- variable regression analysis.
resultsThe research included 1919 patients, of whom 1106 cases (57.63%) had positive urine cultures. In total, 445 blood culture samples were tested, identifying 186 positive cases (41.80%). The prevalence of bacteria in urine and blood samples was highest for Escherichia coli and Klebsiella pneumoniae, respectively. Moreover, 268 individuals (13.97%) exhibited sepsis. The regression analysis indicated a positive correlation between sepsis and albumin (ALB)<34.35 g/L, C-reactive protein (CRP)>55.84 mg/L and white blood cell count (WBC) >8.485 X 109/L in diabetic cases with UTIs. By integrating the three aforementioned parameters, the area under the receiver operating characteristic curve was 0.809.
conclusionsThe early detection of sepsis in diabetic individuals with UTI may be achieved using a comprehensive analysis of CRP, WBC, and ALB test findings.
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