SynthesisOdontology2024
Regeneration of periodontal intrabony defects using platelet-rich fibrin (PRF): a systematic review and network meta-analysis.
Synthesis in Odontology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Efficacy of Leukocyte and Platelet-Rich Fibrin (L-PRF) as an adjunct to Open Flap Debridement (OFD) in periodontal intrabony defects: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Does platelet-rich fibrin enhance the outcomes of peri-implant soft tissues? A systematic review.BMC oral health · 2025Pooled it
- Association of torque teno virus in periodontitis: a systematic review, meta-analysis, and trial sequential analysis.Frontiers in oral health · 2025Pooled it
- Three-year results of a prospective, controlled clinical study evaluating treatment of intra-bony defects with PRF or EMD- a randomized control trial.BMC oral health · 2026Trial
- Evaluation of the usefulness of platelet-rich fibrin (PRF) in mandibular third molar surgery with 3D facial swelling analysis: a split-mouth randomized clinical trial.Head & face medicine · 2025Trial
- Assessment of periodontal regeneration with blood derivatives: a systematic review and network meta-analysis.Odontology · 2026Review
- Platelet-derived concentrates in the immunological management of periodontitis: from dysbiosis to personalized approaches.Odontology · 2026Review
- Platelet Concentrates in Periodontal Regeneration: A Review of Current Evidence and Clinical Perspectives.Cureus · 2026Review
- Tuning Secretomes for Regenerative Medicine.Biology · 2026Review
- Utilization of platelet rich fibrin in soft tissue augmentation around dental implant: a systematic review and meta-analysis.Odontology · 2026Review
- Clinical effectiveness of albumin-enriched platelet-rich fibrin (Alb-PRF) in periodontal and peri-implant regenerative surgery: a systematic review.Odontology · 2026Review
- Preclinical Evaluation of the Effect of Liquid Platelet-Rich Fibrin and a Volume-Stable Collagen Matrix on Periodontal Regeneration.Journal of clinical periodontology · 2026Article
- Bone-Healing Enhancement Using Particulate Biomaterials and Fibrin-Based Compounds: A Narrative Literature Review of Evidence in Animal Models.Materials (Basel, Switzerland) · 2026Review
- Effect of glycaemic control on growth factor release andFrontiers in dental medicine · 2026Article
- Evidence for platelet-rich fibrin in combination with other regenerative materials for treatment of periodontal furcation defects: a systematic review and meta-analysis.American journal of translational research · 2026Article
- Comparison of growth factor concentrations in platelet-rich fibrin biomaterial in different systemic diseases.Clinical oral investigations · 2025Article
- V-ATPase and Lysosomal Energy Sensing in Periodontitis and Medicine-Related Osteonecrosis of the Jaw.Biomolecules · 2025Review
- Radiographic Evaluation in Alveolar Preservation Using Platelet-Rich Fibrin: A Randomized Controlled Trial.Dentistry journal · 2025Article
- PRF and PRP in Dentistry: An Umbrella Review.Journal of clinical medicine · 2025Review
- Long-Term Benefits of Periodontal Regeneration in Severely Compromised Teeth: A Retrospective Case Series.Case reports in dentistry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most promising approaches to correct periodontal bone defects and achieve periodontal regeneration is platelet-rich fibrin (PRF). This systematic review and meta-analysis aimed to evaluate the regeneration of periodontal bone defects using PRF compared to other regenerative treatments. The data search and retrieval process followed the PRISMA guidelines. An electronic search of MEDLINE, Cochrane, and PubMed databases was performed, selecting exclusively randomized clinical trials where the following were measured: probing depth reduction (PD), clinical attachment level gain (CAL), and radiographic bone fill (RBF). Out of 284 selected articles, 32 were chosen based on inclusion criteria. The use of platelet-rich fibrin (PRF) + open flap debridement (OFD), PRF + metformin, PRF + platelet-rich plasma (PRP), and PRF + OFD/bone graft (BG) significantly reduced PD and improved CAL and RBF. However, the combination of PRF + BG, PRF + metformin, and PRF + STATINS reduced CAL. The intervention of PRF combined with different treatments such as metformin, OFD, PRP, BG, and STATINS has a significant impact on improving PD and CAL. The use of PRF significantly improved the regeneration of periodontal bone defects compared to other treatments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.