Evidence map›Paper›PMID 38771487›Full record

ArticleImmunologic research2024

Lupus progression deteriorates oogenesis quality in MRL/lpr mice.

Stefka Delimitreva, Gabriela Boneva, Irina Chakarova, Valentina Hadzhinesheva, Ralitsa Zhivkova, Maya Markova, Venera Nikolova, Anton Kolarov, Nikola Mladenov, Silviya Bradyanova and 3 more

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Article in Immunologic research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stefka DelimitrevaDepartment of Biology, Medical University of Sofia, 2, Zdrave Str., 1431, Sofia, Bulgaria. s.delimitreva@medfac.mu-sofia.bg.
Gabriela BonevaDepartment of Immunology, Stefan Angelov Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 26, 1113, Sofia, Bulgaria.
Irina ChakarovaDepartment of Biology, Medical University of Sofia, 2, Zdrave Str., 1431, Sofia, Bulgaria.
Valentina HadzhineshevaDepartment of Biology, Medical University of Sofia, 2, Zdrave Str., 1431, Sofia, Bulgaria.
Ralitsa ZhivkovaDepartment of Biology, Medical University of Sofia, 2, Zdrave Str., 1431, Sofia, Bulgaria.
Maya MarkovaDepartment of Biology, Medical University of Sofia, 2, Zdrave Str., 1431, Sofia, Bulgaria.
Venera NikolovaDepartment of Biology, Medical University of Sofia, 2, Zdrave Str., 1431, Sofia, Bulgaria.
Anton KolarovDepartment of Biology, Medical University of Sofia, 2, Zdrave Str., 1431, Sofia, Bulgaria.
Nikola MladenovDepartment of Biology, Medical University of Sofia, 2, Zdrave Str., 1431, Sofia, Bulgaria.
Silviya BradyanovaDepartment of Immunology, Stefan Angelov Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 26, 1113, Sofia, Bulgaria.
József PrechlR&D Laboratory, Diagnosticum Zrt, Budapest, Hungary.
Nikolina MihaylovaDepartment of Immunology, Stefan Angelov Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 26, 1113, Sofia, Bulgaria.
Andrey TchorbanovDepartment of Immunology, Stefan Angelov Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 26, 1113, Sofia, Bulgaria. tchorban@microbio.bas.bg.

Funding

Medical University of Sofia 25/2016National Science Fund, Bulgaria КP-06-H53/8/2021the European Fund for regional development through Operational Program Science and Education for Smart Growth 2014 - 2020 the European Fund for regional development through Operational Program Science and Education for Smart Growth 2014 - 2020
6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of the immune response against self antigens. Numerous reproductive complications, including reduced birth rate and complications for the mother and the fetus during pregnancy, have been observed in women with SLE. In the present study, we aimed to investigate the effect of SLE development on oocyte meiosis in lupus-prone mice. Lupus-prone MRL/lpr mice were used for the experiments: disease-free (4 weeks of age) and sick (20 weeks of age, virgin and postpartum). The immune response was monitored by flow cytometry, ELISpot, ELISA, and histology. Oocytes were analyzed by fluorescence microscopy based on chromatin, tubulin, and actin structures. The lupus-prone MRL/lpr mice developed age-dependent symptoms of SLE with increased levels of various autoantibodies, proteinuria, and renal infiltrates and a tendency for the immune response to worsen with changes in cell populations and the cytokine profile. The number and quality of oocytes were also affected, and the successful pregnancy rate of MRL/lpr mice was limited to only 60%. Isolated oocytes showed severe structural changes in all studied groups. Systemic alterations in immune homeostasis in SLE affect the quality of developing oocytes, which is evident from a young age. The data obtained is in line with the trend of reduced fertility in lupus-prone MRL/lpr mice. The phenomenon can be explained by changes in the microenvironment of the relevant organs and close connection between ovulation and inflammatory processes.

Indexed as

AutoantibodiesDisease Models, AnimalLupus Erythematosus, SystemicMice, Inbred MRL lprOocytesOogenesisAnimalsCytokinesDisease ProgressionFemaleHumansMeiosisMicePregnancyAutoantibodiesCytokinesAutoimmunityMRL miceOogenesisSystemic lupus

Identifiers

PMID38771487

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.