Evidence map›Paper›PMID 38771457›Full record

ArticleCell biochemistry and biophysics2024

Connection between MiR-490 and CCND1 and GSK3β genes play an effective role in Wnt signaling pathway in colorectal cancer.

Mahdieh Banoei, Negin Borzooee Moghadam, Erfan Gowdini, Azar Heidarizadi, Saeid Amanpour, Zahra Mohammadi Abgarmi, Majid Pornour, Massimo Negrini, Shahla Mohammad Ganji

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Article in Cell biochemistry and biophysics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mahdieh Banoei *Department of Molecular Medicine, Medical Biotechnology Institute, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Negin Borzooee MoghadamDepartment of Molecular Medicine, Medical Biotechnology Institute, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Erfan Gowdini *Department of Molecular Medicine, Medical Biotechnology Institute, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Azar HeidarizadiDepartment of Molecular Medicine, Medical Biotechnology Institute, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Saeid AmanpourCancer biology research center, Cancer institute, Tehran University of Medical Sciences, Tehran, Iran.
Zahra Mohammadi AbgarmiDepartment of Clinical Biochemistry, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran.
Majid PornourMedical Laser Research Center, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran.
Massimo NegriniDepartment of Experimental Medicine and Diagnostics, University of Ferrara, Ferrara, Italy.
Shahla Mohammad GanjiDepartment of Molecular Medicine, Medical Biotechnology Institute, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran. shahla@nigeb.ac.ir.

Funding

National Institute for Genetic Engineering and Biotechnology 698
6 · The paper itself

Abstract

The Wnt signaling pathway is identified as one of the main disrupted pathways in Colorectal cancer (CRC). Results from studies focusing on this route will aid greatly in the detection and treatment of CRC. MicroRNAs (MiRs), particularly MiR-490, has emerged as key regulator of gene expression in biological pathways, making it an attractive research target. This is notably true for the Wnt signaling pathway, which is usually disordered in CRC tissues. This study aimed to evaluate the expression level of MiR-490 isomiRs and determine some of its key target genes involved in Wnt signaling pathway in CRC tissues and cell lines, based on experimental and bioinformatics analysis. Elevated expression of GSK3β and CCND1 indicate that the progression of CRC tumor is associated with the inhibitory effect of MiR-490 isomiRs on the Wnt/β-catenin signaling pathway. This finding was supported by the observation of a positive connection between the expression pattern of miR-490-3p and 5p, and CCND1 and GSK3β in CRC. The valuable results of this study provide a means of identifying biomarkers with the potential to either inhibit or activate CRC cellular pathways.

Indexed as

Colorectal NeoplasmsCyclin D1Glycogen Synthase Kinase 3 betaMicroRNAsWnt Signaling PathwayCell Line, TumorGene Expression Regulation, NeoplasticHumansCCND1 protein, humanCyclin D1Glycogen Synthase Kinase 3 betaGSK3B protein, humanMicroRNAsMIRN490 microRNA, humanCCND1Colorectal cancer (CRC)GSK3βMiR490-isoMiRsWnt signaling pathway

Identifiers

PMID38771457

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.