Evidence map›Paper›PMID 38771414›Full record

ReviewWorld journal of microbiology & biotechnology2024

Nanobodies in the fight against infectious diseases: repurposing nature's tiny weapons.

Soha S Rizk, Dina M Moustafa, Shahira A ElBanna, Hanzada T Nour El-Din, Ahmed S Attia

Abstract readReview
In one paragraph

Review in World journal of microbiology & biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  3. Article
  4. Article
  5. Review
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  8. Article
  9. Article
  10. Review
  11. The promising potential of camelid nanobodies for nuclear medicine.European journal of nuclear medicine and molecular imaging · 2025
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Soha S RizkMicrobiology and Immunology Postgraduate Program, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Dina M MoustafaDepartment of Medical Sciences, Faculty of Dentistry, The British University in Egypt, El Sherouk City, Cairo, 11837, Egypt.
Shahira A ElBannaDepartment of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Hanzada T Nour El-DinDepartment of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Ahmed S AttiaDepartment of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. ahmed.attia@pharma.cu.edu.eg.

Funding

Academy of Scientific Research and Technology (ASRT), Egypt D62/2020
6 · The paper itself

Abstract

Nanobodies are the smallest known antigen-binding molecules to date. Their small size, good tissue penetration, high stability and solubility, ease of expression, refolding ability, and negligible immunogenicity in the human body have granted them excellence over conventional antibodies. Those exceptional attributes of nanobodies make them promising candidates for various applications in biotechnology, medicine, protein engineering, structural biology, food, and agriculture. This review presents an overview of their structure, development methods, advantages, possible challenges, and applications with special emphasis on infectious diseases-related ones. A showcase of how nanobodies can be harnessed for applications including neutralization of viruses and combating antibiotic-resistant bacteria is detailed. Overall, the impact of nanobodies in vaccine design, rapid diagnostics, and targeted therapies, besides exploring their role in deciphering microbial structures and virulence mechanisms are highlighted. Indeed, nanobodies are reshaping the future of infectious disease prevention and treatment.

Indexed as

Communicable DiseasesSingle-Domain AntibodiesAnimalsBiotechnologyHumansProtein EngineeringSingle-Domain AntibodiesBacteriaDiagnosisInfectious diseasesNanobodiesProphylaxisTreatmentViruses

Identifiers

PMID38771414
PMCPMC11108896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.