Observational studyBreast cancer research and treatment2024
Prognostic significance and value of further classification of lymphovascular invasion in invasive breast cancer: a retrospective observational study.
Observational study in Breast cancer research and treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Accurate assessment of surgical HER2-low status based on core needle biopsy data of breast cancer.Diagnostic and prognostic research · 2026Article
- Prognostic Significance of Lymphovascular Invasion in Breast Cancer: Insights From a Retrospective Analysis at a Tertiary Care Center.Saudi medical journal · 2026Article
- Development and verification of a prognostic nomogram model for triple-negative breast cancer patients with neoadjuvant therapy.Frontiers in oncology · 2026Article
- Pregnancy-associated breast cancer: gestational weight gain impact and nomogram validation.BMC cancer · 2025Article
- Measuring Surgical Waiting Times in Breast Cancer: Admission to Surgery Versus Biopsy Result to Surgery.Healthcare (Basel, Switzerland) · 2025Article
- Preoperative lymph node metastasis risk assessment in invasive micropapillary carcinoma of the breast: development of a machine learning-based predictive model with a web-based calculator.World journal of surgical oncology · 2025Article
- Prognostic Insights in Feline Mammary Carcinomas: Clinicopathological Factors and the Proposal of a New Staging System.Animals : an open access journal from MDPI · 2025Article
- Preoperative Imaging Assessment of Lymphovascular Invasion in Breast Cancer: Current Evidence, Technical Advances, and Future Directions.Breast cancer (Dove Medical Press) · 2025Review
- Prognostic prediction for HER2-low breast cancer patients using a novel machine learning model.BMC cancer · 2024Article
- Mammographic Breast Density at Breast Cancer Diagnosis and Breast Cancer-Specific Survival.Diagnostics (Basel, Switzerland) · 2024Article
- Distribution characteristics of immune infiltration and lymphovascular invasion in patients with breast cancer skin recurrence.Cancer immunology, immunotherapy : CII · 2024Article
- MRI Radiomics-Based Prediction of Occult Sentinel Lymph Node Metastasis and D2-40 Expression in Breast Cancer.Technology in cancer research & treatmentArticle
- Transformer-Based Deep Learning Model Using MRI-Derived Microvascular Atlas for Predicting Lymphovascular Invasion in Breast Cancer Patients.Technology in cancer research & treatmentArticle
- The Impact of Lymphoscintigraphy Visualization on the Prognosis of Early Breast Cancer Patients Undergoing Sentinel Node Biopsy: A 20-year, Single-center Experience.Cancer diagnosis & prognosisArticle
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Authors and funding
6 authors.
Funding
Abstract
purposeTo investigate the prognostic significance of lymphovascular invasion in invasive breast cancer and the value of using specific vascular endothelial markers to further classify lymphovascular invasion.
methodsWe collected 2124 patients with invasive breast cancer who were hospitalized at the First Hospital of Dalian Medical University from 2012 to 2020. Statistical methods were used to investigate the relationship between lymphovascular invasion and clinicopathological characteristics of breast cancer, and the correlation between lymphovascular invasion on overall survival (OS) and disease-free survival (DFS) of various categories of breast cancers. Immunohistochemical staining of breast cancer samples containing lymphovascular invasion using specific vascular endothelial markers D2-40 and CD34 was used to classify lymphovascular invasion and to investigate the relationship between lymphovascular invasion and breast cancer progression.
resultsThere was a high correlation between lymphovascular invasion and T stage, N stage and nerve invasion. Survival analyses showed that patients with lymphovascular invasion, especially luminal B, triple-negative, and Her-2 overexpression breast cancer patients, had poorer OS and DFS prognosis, and that lymphovascular invasion was an independent prognostic factor affecting OS and DFS in breast cancer. The immunohistochemical staining results showed that positive D2-40 staining of lymphovascular invasion was linked to the N stage and localized recurrence of breast cancer.
conclusionLymphovascular invasion is associated with aggressive clinicopathological features and is an independent poor prognostic factor in invasive breast cancer. Breast cancer localized recurrence rate and lymph node metastases are influenced by lymphatic vessel invasion. Immunohistochemical techniques should be added to the routine diagnosis of lymphovascular invasion.
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