Evidence map›Paper›PMID 38771375›Full record

ReviewInnere Medizin (Heidelberg, Germany)2024

[Heritable pulmonary arterial hypertension].

Christina A Eichstaedt, Memoona Shaukat, Ekkehard Grünig

Abstract readReviewEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Review in Innere Medizin (Heidelberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christina A EichstaedtZentrum für Pulmonale Hypertonie, Thoraxklinik am Universitätsklinikum Heidelberg, Röntgenstraße 1, 69126, Heidelberg, Deutschland. christina.eichstaedt@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0001-7288-8297
Memoona ShaukatZentrum für Pulmonale Hypertonie, Thoraxklinik am Universitätsklinikum Heidelberg, Röntgenstraße 1, 69126, Heidelberg, Deutschland.ORCID http://orcid.org/0000-0002-1222-0911
Ekkehard GrünigZentrum für Pulmonale Hypertonie, Thoraxklinik am Universitätsklinikum Heidelberg, Röntgenstraße 1, 69126, Heidelberg, Deutschland.ORCID http://orcid.org/0000-0001-7318-3918

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heritable pulmonary arterial hypertension (PAH) can be triggered by at least 18 genes. The most frequently altered gene is the bone morphogenetic protein receptor 2 (BMPR2). Further genes from the same pathway are also well known PAH-causing genes. Genetic testing can aid to confirm differential diagnoses such as a pulmonary veno-occlusive disease. It also enables the testing of healthy family members. In addition to the PAH patient population particularly served by genetic testing, this article touches on the mode of inheritance and provides insights into the first treatments soon on the market that rebalance the BMPR2 signaling pathway.

Indexed as

Bone Morphogenetic Protein Receptors, Type IIFamilial Primary Pulmonary HypertensionGenetic Predisposition to DiseaseGenetic TestingHumansHypertension, PulmonaryPulmonary Arterial HypertensionSignal TransductionBMPR2 protein, humanBone Morphogenetic Protein Receptors, Type IIBone morphogenetic protein receptor 2 (BMPR2)Genetic testingPulmonary hypertensionPulmonary veno-occlusive diseaseReduced penetranceSotatercept

Identifiers

PMID38771375
PMCPMC11136850

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.