ArticleThe Plant cell2024
SEPALLATA-driven MADS transcription factor tetramerization is required for inner whorl floral organ development.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The phytoplasma effector, phyllogen, structurally mimics host plant MADS transcription factors.The Journal of biological chemistry · 2026Article
- Alphafuser: a parsimonious approach to predicting higher-order protein complexes.Acta crystallographica. Section D, Structural biology · 2026Article
- Functional Analysis of MADS-Box Gene Family in Stress Response and Prospects of Breeding Application.Plants (Basel, Switzerland) · 2026Review
- Integrative transcriptome and genome resequencing reveals conserved flowering regulators and allelic variants in early- and late-flowering linseed (Linum usitatissimum L.) accessions.Scientific reports · 2026Article
- A novel CsbZIP26-CsSEP4-CsSPL18 regulatory module governs gynostemium morphology and floral architecture inHorticulture research · 2026Article
- AP1 is a pioneer transcription factor that programmes cell fate through MADS-domain protein tetramerisation.Genome biology · 2025Article
- The specificity landscape of WRKY transcription factors reveals the bidirectional influence of non-CG methylation.Nucleic acids research · 2025Article
- The blue light receptor ZmFKF1a recruits ZmGI1 to the nucleus to accelerate shoot apex development and flowering in maize.The Plant cell · 2025Article
- Histone acetyltransferase GCN5 orchestrates flower development and is required for proper regulation of multiple key meristem and organ identity genes.The Plant cell · 2025Article
- Site-Directed Mutagenesis Mediated by Molecular Modeling and Docking and Its Effect on the Protein-Protein Interactions of the bHLH Transcription Factors SPATULA, HECATE1, and INDEHISCENT.Plants (Basel, Switzerland) · 2025Article
- The evolution of separate sexes in waterhemp is associated with surprising chromosomal diversity and complexity.PLoS biology · 2025Article
- Transcriptome Analysis Reveals Association of E-Class AmMADS-Box Genes with Petal Malformation inInternational journal of molecular sciences · 2025Article
- The dynamic regulatory network of stamens and pistils in papaya.BMC plant biology · 2025Article
- Article
- Reflections on the ABC model of flower development.The Plant cell · 2024Review
- AGAMOUS mediates timing of guard cell formation during gynoecium development.PLoS genetics · 2023Article
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Authors and funding
16 authors.
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Abstract
MADS transcription factors are master regulators of plant reproduction and flower development. The SEPALLATA (SEP) subfamily of MADS transcription factors is required for the development of floral organs and plays roles in inflorescence architecture and development of the floral meristem. SEPALLATAs act as organizers of MADS complexes, forming both heterodimers and heterotetramers in vitro. To date, the MADS complexes characterized in angiosperm floral organ development contain at least 1 SEPALLATA protein. Whether DNA binding by SEPALLATA-containing dimeric MADS complexes is sufficient for launching floral organ identity programs, however, is not clear as only defects in floral meristem determinacy were observed in tetramerization-impaired SEPALLATA mutant proteins. Here, we used a combination of genome-wide-binding studies, high-resolution structural studies of the SEP3/AGAMOUS (AG) tetramerization domain, structure-based mutagenesis and complementation experiments in Arabidopsis (Arabidopsis thaliana) sep1 sep2 sep3 and sep1 sep2 sep3 ag-4 plants transformed with versions of SEP3 encoding tetramerization mutants. We demonstrate that while SEP3 heterodimers can bind DNA both in vitro and in vivo and recognize the majority of SEP3 wild-type-binding sites genome-wide, tetramerization is required not only for floral meristem determinacy but also for floral organ identity in the second, third, and fourth whorls.
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