Evidence map›Paper›PMID 38770992›Full record

ArticleRenal failure2024

Evidence from mendelian randomization identifies several causal relationships between primary membranous nephropathy and gut microbiota.

Jianwei Wu, Jing Zhang, Gang Huang, Yinglian Zhong, Yi Yang, Peng Deng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jianwei WuDepartment of Medical Technology, Gannan Healthcare Vocational College, Ganzhou, China.
Jing ZhangDepartment of Medical Technology, Gannan Healthcare Vocational College, Ganzhou, China.
Gang HuangDepartment of Laboratory, GanZhou Cancer Hospital, Ganzhou, China.
Yinglian ZhongDepartment of Blood Transfusion, Ganzhou Fifth People's Hospital, Ganzhou, China.
Yi YangDepartment of Rheumatology and Immunology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Peng DengDepartment of Endocrinology, Department of Nephrology, Ganzhou Fifth People's Hospital, Ganzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResearch has showcased a correlation between disruptions in gut microbiota and primary membranous nephropathy (pMN), giving rise to the concept of the 'gut-kidney axis'. However, the precise relationship between gut microbiota and pMN remains elusive. Hence, this study endeavors to investigate whether a causal relationship exists between gut microbiota and pMN utilizing Mendelian randomization (MR) analysis.

methodsThe primary method employed for MR analysis is the inverse variance weighting method, supplemented by MR-Egger and the weighted median method, to infer causality. This approach was validated within the pMN cohort across two distinct populations.

resultsAt the species level, the abundance of

conclusionThese findings lay the groundwork for future research exploring the interplay between pMN and the gut microbiota, with substantial implications for the prevention and treatment of pMN and its associated complications.

Indexed as

Gastrointestinal MicrobiomeGlomerulonephritis, MembranousMendelian Randomization AnalysisAdultBifidobacterium bifidumFemaleHumansMaleMiddle Agedgenome-wide associationGut microbiotamendelian randomizationprimary membranous nephropathy

Identifiers

PMID38770992
PMCPMC11110878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.